1.
Bioorg Med Chem Lett
; 24(6): 1519-22, 2014 Mar 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-24582478
RESUMO
Positron emission tomography (PET) is a highly sensitive quantitative imaging technique for studying molecular pathways and interactions in vivo. This imaging technique plays a key role in drug discovery, pharmacokinetics, pharmacodynamics, and assessing in vivo distribution. In this study, we designed an ethynylbenzene-substituted glycol (M(E)) as a versatile probe for PET labeling of oligonucleotides through a click reaction.