[Homeostatic and antioxidant defense enzymes activity in chronic pyelonephritis]. / Pokazateli gomeostaza i funktsional'noe sostoianie fermentov antioksidantnoi zashchity pri khronicheskom pielonefrite.

As shown by the analysis of chronic pyelonephritis, manifestations in patients with high and low activity of antioxidant system enzymes, patients with high catalase activity have more effective defense of red cells, glomerular epithelium. This was concluded from marked differences in urinary excretion of metabolites, hemoglobin levels compared to those in patients with low activity of catalase. In low activity of glutathione peroxidase, inflammation gains activity, nonspecific resistance weakens, excretion of some metabolites inhibits vs patients with high activity of this enzyme. The data provide criteria for diagnosis of antioxidant system defects and show necessity of antioxidant drugs inclusion into the therapeutic scheme (unitiol, antioxidant complex of vitamins A, E, C, P).

[Membranous aspects of kidney transplantation and reasons of transplant antioxidant defense]. / Membranologicheskie aspekty peresadki pochki i obosnovanie antioksidantnoi zashchity transplantanta.

Special membranological studies of the role of antioxidant emoxipine in combined pharmacological support of stable function of the transplanted kidney in 30 patients have shown that this drug restores phospholipid pool of red cell membranes and improves their physical properties. No significant fluctuations of cyclosporin A blood concentrations were registered. Emoxipine addition to combined therapy of patients with transplanted kidney is recommended.