[The effect of diltiazem on neurohumoral regulatory mechanisms in stenocardia patients]. / Vliianie diltiazema na neirogumoral'nye mekhanizmy reguliatsii u bol'nykh stenokardiei.

Effects were studied of diltiazem on parameters characterizing cardiohemodynamics, peripheral bloodflow, condition of atrial natriuretic peptide (ANUP), of cyclic nucleotides (cGMP), the renin-angiotensin system in patients with various manifestations of stenocardia. An inhibitory action of diltiazem on ANUP and cGMP secretion in a VEM-test was recordable but changes were not significant at the height of the drug action in rest. Improvement in myocardial contractility after the course treatment with the drug was accompanied by reduction in blood plasma levels of ANUP and cGMP. It is suggested that changes in ANUP concentration might be traced to improvement in the anginal course and to the drug effects such as lowering of myocardial oxygen demand, of pre- and afterload, improvement in the indices for myocardial contractility.