FEATURES OF MORPHOGENESIS OF THE BONES OF THE HUMAN ORBIT.

OBJECTIVE: The aim: To find out the sources of origin, the chronology of ossification, the peculiarities of age-related topographical and anatomical changes in the bones of the human orbit. PATIENTS AND METHODS: Materials and methods: The research was carried out on the specimens of 18 human embryos and prefetuses aged from 4th to 12th weeks of intrauterine development and 12 human fetuses aged from 4th to 9th months which were studied by microscopic examination and 3D reconstruction. RESULTS: Results: The first signs of osteogenesis around the main nervous and visceral contents of the orbit rudiment are observed in 6-week-old embryos in the form of seven cartilaginous bone models. The first signs of ossification in the region of the orbit are found in the maxilla. During the 6th month of intrauterine development, intensive processes of ossification of the frontal, sphenoidal, ethmoidal bones and maxilla are noticeable. From the beginning of the fetal pe¬riod of human ontogenesis, the ossification of bone rudiments that form the walls of the orbit continues. The processes of ossification of the structures of the sphenoidal bone continue, which leads to morphological transformations of the orbit in 5-month-old fetuses - it is separated from the sphenopalatine and infratemporal fossae by a bone layer, the optic canal is formed, and in 6-month-old fetuses, processes of ossification of the frontal, sphenoidal and ethmoidal bones and maxilla occur, Müller's muscle changes its structure to a fibrous one. CONCLUSION: Conclusions: Critical periods of the orbit development are the 6th month of prenatal ontogenesis and the 8th month.

PECULIARITIES OF THE HUMAN MAXILLA MORPHOGENESIS.

OBJECTIVE: The aim: To find out the sources of formation and the chronological sequence of the morphogenesis of the maxilla at the early stages of human ontogenesis. PATIENTS AND METHODS: Materials and methods: 14 series of consecutive histological specimens of human embryos and prefetuses (4,0-66,0 mm of parietal-coccygeal length) aged from 4 to 11 weeks of intrauterine development with the use of a complex of modern morphological methods of investigation (anthropometry, morphometry, microscopy, and 3D computer reconstruction) were studied. RESULTS: Results: On the basis of a complex of morphological research methods, data were obtained that made it possible to establish the general patterns of development of the human maxilla: separation of the pharyngeal apparatus (4th week), convergence and fusion of the jaw processes (5-8th weeks), formation of tooth buds (7-8th weeks), which allows considering the specified periods as critical in the formation of possible anomalies in the facial part of the skull. At the same time, a tendency of heterochrony of morphological transformations in the maxilla and maxilla was revealed. CONCLUSION: Conclusions: 1. At the beginning of the 4th week of intrauterine development, 3 pairs of pharyngeal arches are formed. Detachment of the mandibular and maxillary processes of the mandibular pharyngeal arch is planned. 2. During the 7th week of intrauterine development, the maximum convergence of the maxillary processes with the lateral and medial nasals occurs, and in embryos of 20.0 mm PCL grow with the frontal process, forming the maxilla and upper lip. During the 8th week of intrauterine development, the bone base of the jaws is modeled as a result of the increase in the size of osteogenic islands and their fusion, alveolar processes are formed. 3. During the 9-10th weeks of intrauterine development, the primary palate is formed as a result of the fusion of the palatine processes. 4. At the 11th week of intrauterine development, the bone base models both jaws. Due to the processes of histogenesis of the soft tissues of the maxillofacial apparatus, the face acquires anthropomorphic definitive human features.

PECULIARITIES OF THE SOURCES OF ORIGIN AND MORPHOGENESIS OF THE HUMAN MANDIBLE.

OBJECTIVE: The aim: To determine the sources and terms of origin, developmental peculiarities and dynamics of ossification of the mandible during the prenatal period of human ontogenesis. PATIENTS AND METHODS: Materials and methods: The research was carried out on the specimens of 30 embryos, 30 pre-fetuses and 60 human fetuses at the period from the 9th to the 12th weeks of the intrauterine development, which were studied by microscopic examination. Three-dimensional computer reconstructions of the human pre-fetal head were made. RESULTS: Results: During the 7th week of development the maxillary processes maximum approach the lateral and medial nasal ones; in pre-fetuses 20,0 mm of PCL they join the frontal spindle forming the facial structures (upper jaw and lip, vestibule of the oral cavity, rudiments of dental laminas, and rudiments of dental buds in its distal portions). Osteogenous islets, rudiments of the mimic and masticatory muscles, blood vessels are formed. During the 8th week of development the osseous tissue of the mandible is formed, the alveolar processes are formed. The oral and nasal cavities are isolated in 9-10-week pre-fetuses, the mass of the osseous tissue increases in both jaws, the enamel organs are detached, the angles and rami formed by the hyaline cartilaginous tissue of the mandible are determined, the rudiments of the temporomandibular joints are already seen. During the 11th week of development the osseous base of both jaws become formed. Till the end of the 12th week the osseous tissue begins to replace the hyaline cartilage of the mandibular rami, and the articular heads are formed in the portion of their proximal ends. CONCLUSION: Conclusions: The mandible in its development is known to be characterized by intra-cartilaginous formation of the bone which starts from the ends of the cartilage gradually displaced by the osseous tissue. It is indicated that both jaws in pre-fetuses 37,0 and 42,0 mm of PCL are presented by the typical cartilaginous tissue, and in pre-fetuses 45,0-50,0 mm of PCL the osseous tissue is already available replacing the cartilaginous one.