[Effect of alpha-acidic glycoprotein on oxyproline metabolism in experimental thermal trauma]. / Vliianie alpha-kislogo glikoproteina na obmen oksiprolina pri éksperimental'noi termicheskoi travme.

alpha 1-Acid glycoprotein, isolated from human blood plasma, was shown to accelerate healing of burn wounds in rats and to increase daily urine excretion. The glycoprotein restricted an elevation of the peptide-bound hydroxyproline in blood plasma, decreased the ratio between peptide-bound and free hydroxyproline within all the periods of experiment during 3 weeks as well as stimulated hydroxyproline excretion with urine at the step of active reparation of burn wounds. The glycoprotein appears to protect connective tissue metabolism in burns.

[The therapeutic properties of an alcohol extract of plasma in a combined radiation-thermal lesion]. / Issledovanie terapevticheskikh svoistv spirtovogo ékstrakta plazmy pri kombinirovannom radiatsionno-termicheskom porazhenii.

The intravenous injection of an alcoholic plasma extract to mice after the combined exposure to radiation and heat decreases lethality, restores the investigation-and-orientation activities and oxygen consumption, favors the growth of body mass and healing of burns. The antioxidant effect of the extract manifests itself by the decreased rate of formation of lipid peroxidation products in the liver and the suppressed spontaneous and latex-induced chemiluminescence of neutrophils.

[Experimental therapy of thermal burns with biogenic peptide-containing preparations]. / Eksperimental'naia terapiia termicheskikh ozhogov biogennymi peptidsoderzhashchimi preparatami.

The authors studied the therapeutic activity of biogenic peptide-containing preparations derived from microbial cell membrane fractions, solcoseryl, and plasma alcohol extract (PAE) in experimental thermal trauma. Treatment of the burnt animals with solcoseryl and PAE reduced mortality to 40-42%, accelerated the healing of the burn wound, restored the behavior status, and increased the intensity of oxygen consumption. This is evidence of the promising character of further studies of the biological activity and therapeutic properties of these preparations.