Positively charged collective oscillations induce efficient Aß1-42 fibril degradation in the presence of novel Au@Cu2-xS core/shell nanorods.

We synthesized Au@Cu2-xS core/shell nanorods (NRs) that have synergistic surface plasmon resonance (SPR) effects using a new cation exchange process in ethylene glycol (EG) phase. The dual effect - NIR photothermal and surface positive charge plasmon - of Au@Cu2-xS NRs, promote the capability to degrade Aß1-42 fibrils into amorphous protein.