[Clinical study of allylestrenol (Perselin) on patients with prostatic hypertrophy].

The efficacy and safety of allylestrenol were studied in 22 patients with benign prostatic hypertrophy. A 25 mg allylestrenol tablet (Perselin tablet) was administered twice a day. A significant decrease in frequency of nocturnal urination was observed and improvement rates of subjective symptoms, such as sensation of residual urine, delay in start of urination, straining during urination and strength of urinary stream, were 59.1-68.2%. The rate of decrease of maximum area of transverse plane of prostate estimated by transrectal sonography was 13.2% and presumed circle area ratio (PCAR) improved significantly. The incidence of total side effects was 22.7%, whereas a decrease in sexual potency was observed in only 4.5% of the cases. The final global improvement rating of allylestrenol was 72.2% and the rate of usefulness was estimated in 63.6% of the patients. The present findings confirmed that allylestrenol is a useful and safe drug for the treatment of benign prostatic hypertrophy.

[Spina bifida accompanied with neurogenic bladder in a patient who lived to be 81 years old].

Spina bifida accompanied with neurogenic bladder in a woman who lived to be 81 years old was reported. Owing to spina bifida (paralyzed below L4), she suffered from urinary incontinence and gait disturbance. Since childhood, she had voided by Credé's maneuver and used a diaper for urinary incontinence. At the age of 56 years old, cystostomy operation was performed for incontinence. After that, she was free from incontinence. The main reason for her longevity was supposed to be the fact that she could accept good medical care and warm family support. Finally she died of lower abdominal carcinoma.