Prediction of Bayley and Stanford-Binet scores with a group of very low birthweight children.

AIM: To study the prediction of cognitive development with a group of very low birthweight infants (<1500 g) at 18 months and at 4 years of age. METHODS: Bayley Scales of Infant Development-II Mental Development Indexes (MDI), and Stanford-Binet Intelligence Scale (S-B) Composite Scores were studied in a population of 334 children with birthweights <1500 g. Independent variables measured were gestational age, birthweight, gender and parental socio-economic status (SES). RESULTS: Longer gestation (28 weeks and over) and higher birthweight (1000-1500 g) proved to be advantageous for cognitive ability at both 18 months and 4 years. Other significant advantages were associated with female and higher SES. High correlations were found between MDI and the S-B Composite Score (r = 0.62), and between birthweight and gestation (r = 0.72). When information available at birth was included in forward stepwise regression analyses to predict the S-B Composite at 4 years, the best predictors were MDI at 18 months and SES. CONCLUSION: With the measures employed and this population, prediction of cognitive development from early childhood to preschool was possible. This may enable reliable identification of those children at risk for delayed cognitive development who require intervention before starting school.

Visual behaviour and dyadic interaction between people with intellectual disability and people who are non-disabled.

Patterns of visual dominance in human interaction have been studied by a number of authors. The purpose of the present research was to investigate the implications of these studies for interaction between people who are disabled and people who are non-disabled. It was predicted that disability would differentiate the two groups, with non-disabled partners dominating the visual interaction. Two studies are reported. The first looked at visual interaction through the two looking modes of looking while listening and looking while speaking between 16 dyads where one partner was intellectually disabled and the other non-disabled. In the second study, eight subjects who were intellectually disabled and who had participated in the first study interacted with another person who had an intellectual disability. Their looking modes were then compared between conversing with a non-disabled partner in study 1 and with those of their partner with intellectual disability in study 2. The outcome of the studies showed that subjects who were intellectually disabled did not discriminate in looking mode between partners of different intellectual levels. Conversely, subjects who were non-disabled spoke and looked significantly more when conversing with their partner who was intellectually disabled. It has been argued that overlooking and overspeaking could arise from the need for the non-disabled person to gain some sign of affiliation from their partner, or alternatively, that it might reflect a dominant non-disabled person attempting to facilitate a cooperative style.

Renin inhibitors. Synthesis of transition-state analogue inhibitors containing phosphorus acid derivatives at the scissile bond.

The synthesis of five amino phosphorus derivatives, 1a-e, is described. The derivatives were incorporated into a series (18) of analogues of the 5-14 portion of angiotensinogen, in most cases at the scissile Leu-Val bond. The resultant compounds were tested in vitro for their ability to inhibit human plasma renin. Replacement of the scissile bond with the phosphinic analogue of Leu10-Val11 (1b) gave the most potent inhibitors, having IC50 = 7.5 x 10(-8) M for H-Pro-His-Pro-Phe-His-(1b)-Ile-His-Lys-OH and IC50 = 1.0 x 10(-7) M for Z-Arg-Arg-Pro-Phe-His-(1b)-Ile-His-NH2. The shorter phosphonic acid sequence Z-Pro-Phe-His-(1d) retained biological activity with an IC50 = 6.4 x 10(-6) M.

Justification and operation of a critical-care satellite pharmacy.

Development and implementation of a pharmacy satellite for critical-care areas in a 700-bed community hospital are described. Before the satellite, central-pharmacy personnel filled 70% of critical-care orders; the remainder of medications were floor stock. Large-volume admixtures were prepared by nurses on the critical-care units. In planning for a satellite pharmacy, turn-around time and lost drug charges were studied. Workload and staffing projections and potential expenses and revenues associated with the proposed satellite were presented to the hospital administration. The satellite was approved and serves 82 beds including the critical-care areas. It is open 16.5 hours/day and provides all i.v. admixtures. Drug distribution is computerized, and pharmacists participate on the CPR team and on physician rounds. Data collected four months after the satellite opened showed shorter turnaround time, decreased floor stock inventory, fewer lost charges, and additional revenue from preparation of i.v. admixtures. Ten months after the satellite was opened, a unit dose system was implemented. Through implementation of the satellite, shorter turnaround time for medication orders and i.v. admixtures, improved drug control, and greater control over billing were achieved.

System to measure the use of pharmacy personnel.

The development of a program to monitor the use of pharmacy personnel is described. The program is part of a hospital-wide Labor Information System developed to support requests for additional staff, to highlight opportunities for improved and allocation of manpower, and to serve as a conceptual model of the department from a manpower perspective when communicating with other members of the hospital organization. Nine major functions of the pharmacy department were identified. Detailed activities for each function were listed along with the type of personnel who performed each activity. Standards representing the amount of time spent on each activity were then developed. Variable, fixed, and open standards were used. Workload volumes are tabulated on a biweekly basis and entered into a computer. Payroll data covering the same period are simultaneously fed into the computer system. The resulting computer-generated report compares the service hours necessary to perform the actual workload (based on the predetermined time standards) to the available hours actually worked by each job category of pharmacy personnel. The ratio of service hours to available hours measures the use of personnel by functional activity. The system has been successfully applied to support requests for additional personnel, to forecast staffing needs for new programs, and to make operational improvements. In addition, the system has the capacity to accurately monitor personnel time for providing clinical services.

Judged attractiveness in recognition memory of women's faces.

A series of 35 3 1/2 X 2 1/2-in., full-face photographs of female undergraduates were used as stimuli. Each subject rated the randomly presented photographs into high, medium, and low attractiveness and 2 hr. later subjects recognized photographs they judged most and least attractive significantly better than the more "neutral" faces when all were mixed with 10 previously unused control stimuli. Arousal and "distinctive cues" were discussed as possible explanations for the improved memory associated with attractive and unattractive faces.