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1.
Rev Esp Anestesiol Reanim (Engl Ed) ; 71(2): 112-124, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-38244774

RESUMO

Septic shock is a highly lethal and prevalent disease. Progressive circulatory dysfunction leads to tissue hypoperfusion and hypoxia, eventually evolving to multiorgan dysfunction and death. Prompt resuscitation may revert these pathogenic mechanisms, restoring oxygen delivery and organ function. High heterogeneity exists among the determinants of circulatory dysfunction in septic shock, and current algorithms provide a stepwise and standardized approach to conduct resuscitation. This review provides the pathophysiological and clinical rationale behind ANDROMEDA-SHOCK-2, an ongoing multicenter randomized controlled trial that aims to compare a personalized resuscitation strategy based on clinical phenotyping and peripheral perfusion assessment, versus standard of care, in early septic shock resuscitation.


Assuntos
Choque Séptico , Humanos , Choque Séptico/terapia , Hidratação , Ressuscitação , Algoritmos , Estudos Multicêntricos como Assunto
2.
Hipertens. riesgo vasc ; 40(2): 58-64, abr.-jun. 2023. tab
Artigo em Inglês | IBECS | ID: ibc-220587

RESUMO

Introduction: Arterial hypertension (AHT), a leading risk factor in terms of attributable mortality, is a major public health problem, especially for primary care where most patients are diagnosed and followed up. Correct AHT diagnosis requires adequate theoretical knowledge and technical skills in physicians and nurses. The aim of this study was to evaluate the knowledge and skills used in initial AHT diagnosis by health professionals and to describe the factors that contribute to variability. Methodology: Cross-sectional observational study in a sample of 385 primary care physicians and nurses recruited in a Catalan health region. Using a validated questionnaire called ARC, we evaluated theoretical knowledge and analysed factors that may contribute to response variability. We also evaluated practical measurement skills using objective structured clinical examination tests. Results: Medical and nursing primary care professionals had deficient knowledge and skills for initial AHT diagnosis and measurement, despite self-perceiving their knowledge to be sufficient. However, professionals who had received postgraduate or other AHT training in the previous year scored better in the ARC questionnaire. Conclusions: The results of this study point to insufficient AHT expertise to ensure quality clinical practice, suggesting that ongoing theoretical and practical training needs to be improved. (AU)


Introducción: La hipertensión arterial (HTA) es un factor de riesgo destacado en términos de mortalidad atribuible, y un gran problema de salud pública, en especial para la atención primaria, donde se diagnostica y se realiza el seguimiento a la mayoría de los pacientes. El diagnóstico correcto de HTA requiere un conocimiento teórico y una competencia técnica adecuados por parte de médicos y enfermeros. El objetivo de este estudio fue evaluar el conocimiento y las competencias aplicados al diagnóstico inicial de HTA por parte de los profesionales sanitarios, así como describir los factores que contribuyen a la variabilidad. Metodología: Estudio observacional transversal de una muestra de 385 médicos y enfermeros de atención primaria seleccionados en una región sanitaria de Cataluña. Utilizando un cuestionario validado denominado ARC, evaluamos el conocimiento técnico y analizamos los factores que probablemente contribuyen a la variabilidad de la respuesta. También evaluamos las técnicas prácticas de medición utilizando una prueba de examen clínico objetivo. Resultados: Los profesionales médicos y enfermeros de atención primaria tenían un conocimiento deficiente para realizar el diagnóstico y la medición iniciales de HTA, a pesar de autopercibir que dicho conocimiento es suficiente. Sin embargo, los profesionales que recibieron formación de posgrado en HTA durante el último año obtuvieron una mejor puntuación en el cuestionario ARC. Conclusiones: Los resultados de este estudio señalan una experiencia insuficiente sobre HTA para garantizar una práctica clínica de calidad, lo cual demuestra que debe mejorarse la formación teórica y práctica continua. (AU)


Assuntos
Humanos , Masculino , Feminino , Adulto Jovem , Adulto , Pessoa de Meia-Idade , Hipertensão/diagnóstico , Conhecimento , Aptidão , Estudos Transversais , Inquéritos e Questionários , Espanha , Pessoal de Saúde , Atenção Primária à Saúde
3.
Hipertens Riesgo Vasc ; 40(2): 58-64, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-36372649

RESUMO

INTRODUCTION: Arterial hypertension (AHT), a leading risk factor in terms of attributable mortality, is a major public health problem, especially for primary care where most patients are diagnosed and followed up. Correct AHT diagnosis requires adequate theoretical knowledge and technical skills in physicians and nurses. The aim of this study was to evaluate the knowledge and skills used in initial AHT diagnosis by health professionals and to describe the factors that contribute to variability. METHODOLOGY: Cross-sectional observational study in a sample of 385 primary care physicians and nurses recruited in a Catalan health region. Using a validated questionnaire called ARC, we evaluated theoretical knowledge and analysed factors that may contribute to response variability. We also evaluated practical measurement skills using objective structured clinical examination tests. RESULTS: Medical and nursing primary care professionals had deficient knowledge and skills for initial AHT diagnosis and measurement, despite self-perceiving their knowledge to be sufficient. However, professionals who had received postgraduate or other AHT training in the previous year scored better in the ARC questionnaire. CONCLUSIONS: The results of this study point to insufficient AHT expertise to ensure quality clinical practice, suggesting that ongoing theoretical and practical training needs to be improved.


Assuntos
Hipertensão , Médicos , Humanos , Estudos Transversais , Hipertensão/diagnóstico , Inquéritos e Questionários , Fatores de Risco
6.
Hipertens Riesgo Vasc ; 39(1): 24-33, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35058163

RESUMO

INTRODUCTION: Arterial hypertension is the main factor in attributable mortality. It is therefore considered one of the most important public health problems. Health professionals require special training and skills to make a diagnosis. No studies have been found in the literature search that use a validated instrument (questionnaire) to assess health professionals' theoretical and practical knowledge in diagnosing hypertension or measuring blood pressure. AIM: To design and validate an instrument for gauging health professionals' theoretical knowledge in measuring blood pressure for the initial diagnosis of hypertension. METHODOLOGY: Design, development, and validation of a questionnaire in three languages (English, Spanish, and Catalan) to assess knowledge based on the Rasch-item response theory model. RESULTS: A questionnaire in three languages was constructed and validated. It consisted of 23 questions on the theoretical knowledge of the initial diagnosis of hypertension and was called the ARC questionnaire. It met all the Rasch-IRT model criteria: item- and person-fit measurement, unidimensionality, local independence, invariance, targeting, and reliability. CONCLUSIONS: The ARC questionnaire is a validated tool that enables objective and uniform analyses of knowledge in the initial diagnosis of hypertension among medical and nursing professionals, comparing them over time. It allows for established strategies to be developed to enhance this knowledge.


Assuntos
Conhecimentos, Atitudes e Prática em Saúde , Hipertensão , Humanos , Hipertensão/diagnóstico , Idioma , Reprodutibilidade dos Testes , Inquéritos e Questionários
7.
Hipertens. riesgo vasc ; 39(1): 24-33, ene-mar 2022. ilus, tab
Artigo em Inglês | IBECS | ID: ibc-203948

RESUMO

Introduction: Arterial hypertension is the main factor in attributable mortality. It is therefore considered one of the most important public health problems. Health professionals require special training and skills to make a diagnosis. No studies have been found in the literature search that use a validated instrument (questionnaire) to assess health professionals’ theoretical and practical knowledge in diagnosing hypertension or measuring blood pressure. Aim: To design and validate an instrument for gauging health professionals’ theoretical knowledge in measuring blood pressure for the initial diagnosis of hypertension. Methodology: Design, development, and validation of a questionnaire in three languages (English, Spanish, and Catalan) to assess knowledge based on the Rasch-item response theory model. Results: A questionnaire in three languages was constructed and validated. It consisted of 23 questions on the theoretical knowledge of the initial diagnosis of hypertension and was called the ARC questionnaire. It met all the Rasch-IRT model criteria: item- and person-fit measurement, unidimensionality, local independence, invariance, targeting, and reliability. Conclusions: The ARC questionnaire is a validated tool that enables objective and uniform analyses of knowledge in the initial diagnosis of hypertension among medical and nursing professionals, comparing them over time. It allows for established strategies to be developed to enhance this knowledge.(AU)


Introducción: La hipertensión arterial es el principal factor de mortalidad atribuible. Es por eso que se considera uno de los problemas de salud pública más importantes. Los profesionales de la salud necesitan una formación y unas habilidades especiales para realizar un diagnóstico. En la literatura actual no se han encontrado estudios que utilicen un instrumento validado (cuestionario) para evaluar los conocimientos teóricos y prácticos de los profesionales de la salud en el diagnóstico de la hipertensión o medición de la tensión arterial. Objetivo: Diseñar y validar un instrumento para medir los conocimientos teóricos de los profesionales de la salud en la medida de la tensión arterial para el diagnóstico inicial de la hipertensión. Metodología: Diseño, desarrollo y validación de un cuestionario en tres idiomas (inglés, español y catalán) para evaluar los conocimientos basados en el modelo de Rasch (teoría de la respuesta al ítem). Resultados: Se construyó y validó un cuestionario en tres idiomas. Constaba de 23 preguntas sobre los conocimientos teóricos en el diagnóstico inicial de hipertensión que se denominó cuestionario ARC. Cumplió con todos los criterios del modelo Rasch-IRT: medición de ajuste (fit) al ítem y a la persona, unidimensionalidad, independencia local, invarianza, targeting y fiabilidad. Conclusiones: El cuestionario ARC es una herramienta validada que permite realizar análisis objetivos y uniformes de los conocimientos en el diagnóstico inicial de la hipertensión entre profesionales de medicina y de enfermería, comparándolos en el tiempo. Permite desarrollar estrategias establecidas para potenciar este conocimiento.(AU)


Assuntos
Humanos , Pessoal de Saúde , Atenção Primária à Saúde , Hipertensão , Conhecimento , Estudos de Validação como Assunto , Inquéritos e Questionários
8.
SEMERGEN, Soc. Esp. Med. Rural Gen. (Ed. Impr.) ; 43(4): 277-288, mayo-jun. 2017. tab, ilus, graf
Artigo em Espanhol | IBECS | ID: ibc-163412

RESUMO

Objetivo. Evaluar la persistencia terapéutica, el coste sanitario y las reacciones adversas en pacientes tratados con oxibutinina y mirabegrón para el tratamiento de la vejiga hiperactiva en condiciones de práctica médica habitual. Pacientes y métodos. Se diseñó un estudio observacional, multicéntrico, retrospectivo, realizado a partir de registros médicos de pacientes pertenecientes a 3 áreas geográficas distintas (Barcelona, Girona, Asturias). Se analizaron los 2 grupos de estudio (oxibutinina y mirabegrón). El seguimiento se realizó durante un año. La persistencia se definió como el tiempo (meses) sin abandono del tratamiento inicial o sin cambio a otra medicación al menos 60 días después de la prescripción inicial. Principales medidas: comorbilidad, uso de recursos sanitarios y reacciones adversas. Programa SPSSWIN; p<0,05. Resultados. Se analizaron 1.277 sujetos. La media de edad fue de 69,3 años y el 53,2% fueron mujeres. Por grupos: 42,9% oxibutinina y 57,1% mirabegrón. Las características demográficas y la morbilidad fueron parecidas. Los pacientes en tratamiento con oxibutinina en comparación con mirabegrón presentaron una similar persistencia al tratamiento (35,0 vs. 32,2%, p=0,294), aunque menores costes (1.151,2 vs. 1.809,6€, p<0,001). Las diferencias mayores se observaron en el precio de la medicación (279,2 vs. 692,3€, p<0,001; diferencia: −4131,€) y en las reacciones adversas (9,7 vs. 4,9%, p<0,001). Conclusiones. Los pacientes en tratamiento con oxibutinina frente a mirabegrón para la vejiga hiperactiva se asociaron a una parecida persistencia al tratamiento, menores costes sanitarios y mayores tasas de reacciones adversas de oxibutinina frente a mirabegrón


Objective. To evaluate therapeutic persistence, healthcare resources, medical costs and adverse events of oxybutynin and mirabegron treatments in patients with overactive bladder in routine medical practice. Patients and methods. An observational, retrospective, multicentre study was carried out using the records of patients attended to in 3 different geographic locations (Barcelona, Girona, Asturias). An analysis was made on the 2 study groups (oxybutynin and mirabegron). Follow-up time was one year. Persistence was defined as the time (months), without discontinuation of the initial treatment, or without change of treatment at least 60 days after the initial prescription. Primary endpoints: comorbidity, healthcare resources used, and adverse events. The data was analysed using the SPSSWIN Program, with a significance of P<.05. Results. Of the total of1,277 patients included in the study, 42.9% were on oxybutynin and 57.1% mirabegron. The mean age was 69.3 years and 53.2% were female. Demographic characteristics and morbidity were similar between the drugs and had a similar persistence (35.0% oxybutynin vs. 32.2% mirabegron, P=.294), although their costs were lower (1,151.2 vs. €1,809.6, P<.001). The biggest differences were observed in the price of medication (279.2 vs. €692.3, P<.001; a variation of: −€413.1); and adverse events (9.7 vs. 4.9%, P<.001). Conclusions. Patients treated with oxybutynin vs. mirabegron for overactive bladder had similar persistence with the treatment, lower healthcare costs, but with higher oxybutynin vs. mirabegron adverse reaction rates (AU)


Assuntos
Humanos , Bexiga Urinária Hiperativa/tratamento farmacológico , Custos de Medicamentos , Antagonistas Colinérgicos/efeitos adversos , Antagonistas Colinérgicos/uso terapêutico , Ácidos Mandélicos/uso terapêutico , Estudos Retrospectivos , Comorbidade , Antagonistas Colinérgicos/economia , Ácidos Mandélicos/efeitos adversos
9.
Semergen ; 43(4): 277-288, 2017.
Artigo em Espanhol | MEDLINE | ID: mdl-27371430

RESUMO

OBJECTIVE: To evaluate therapeutic persistence, healthcare resources, medical costs and adverse events of oxybutynin and mirabegron treatments in patients with overactive bladder in routine medical practice. PATIENTS AND METHODS: An observational, retrospective, multicentre study was carried out using the records of patients attended to in 3 different geographic locations (Barcelona, Girona, Asturias). An analysis was made on the 2 study groups (oxybutynin and mirabegron). Follow-up time was one year. Persistence was defined as the time (months), without discontinuation of the initial treatment, or without change of treatment at least 60 days after the initial prescription. Primary endpoints: comorbidity, healthcare resources used, and adverse events. The data was analysed using the SPSSWIN Program, with a significance of P<.05. RESULTS: Of the total of1,277 patients included in the study, 42.9% were on oxybutynin and 57.1% mirabegron. The mean age was 69.3 years and 53.2% were female. Demographic characteristics and morbidity were similar between the drugs and had a similar persistence (35.0% oxybutynin vs. 32.2% mirabegron, P=.294), although their costs were lower (1,151.2 vs. €1,809.6, P<.001). The biggest differences were observed in the price of medication (279.2 vs. €692.3, P<.001; a variation of: -€413.1); and adverse events (9.7 vs. 4.9%, P<.001). CONCLUSIONS: Patients treated with oxybutynin vs. mirabegron for overactive bladder had similar persistence with the treatment, lower healthcare costs, but with higher oxybutynin vs. mirabegron adverse reaction rates.


Assuntos
Acetanilidas/administração & dosagem , Ácidos Mandélicos/administração & dosagem , Tiazóis/administração & dosagem , Bexiga Urinária Hiperativa/tratamento farmacológico , Agentes Urológicos/administração & dosagem , Acetanilidas/efeitos adversos , Acetanilidas/economia , Adolescente , Adulto , Idoso , Feminino , Seguimentos , Custos de Cuidados de Saúde , Humanos , Masculino , Ácidos Mandélicos/efeitos adversos , Ácidos Mandélicos/economia , Adesão à Medicação , Pessoa de Meia-Idade , Estudos Retrospectivos , Espanha , Tiazóis/efeitos adversos , Tiazóis/economia , Bexiga Urinária Hiperativa/economia , Agentes Urológicos/efeitos adversos , Agentes Urológicos/economia , Adulto Jovem
10.
Salud(i)ciencia (Impresa) ; 21(8): 824-831, abr. 2016. graf., tab., ilus.
Artigo em Espanhol | BINACIS, LILACS | ID: biblio-1116853

RESUMO

Background and objective: With the development of image processing techniques, it has become possible to measure the changes in retinal vessels of hypertensive patients by means of eye fundus photographs. Patients and method: In this paper we aim to classify retinal vessels automatically into arterioles and venules. In order to do so, we have compared three different strategies based on the colour of the pixels in images through an analysis of 78 hypertensive patients' eye fundus images. The first strategy classifies all the vessels by applying a clustering algorithm. The second divides the retinal image into four quadrants and classifies the vessels that belong to the same quadrant independently from the rest of the vessels. The third strategy classifies the vessels by dividing the retinal image into four quadrants that are rotated inside the mentioned image. Results: The third strategy was the one that obtained the best results, since it minimizes the number of unclassified vessels. In the initially analysed set of 20 images, we correctly classified 86.53% of the vessels, and this percentage remains similar in a set of 58 images examined by three medical experts. This confirms the validity of the method that automatically calculates the arteriovenous ratio (AVR).Conclusion: Our results are an improvement on those previously described in the bibliography, reducing the number of non-classified vessels. Furthermore, the method entails low computational costs.


Fundamento y objetivo: El desarrollo de técnicas de procesado de imágenes ha devuelto interés para poder medir de una forma objetiva los cambios en la estructura microvascular del hipertenso a través de las fotografías digitales del fondo de ojo. Pacientes y método: Para clasificar de forma automática los vasos de la retina en arteriolas y vénulas, con una elevada precisión, hemos comparado tres estrategias diferentes basadas en la información del color de los pixeles de la imagen del fondo de ojo, analizando 78 imágenes de fondo de ojo de hipertensos. La primera estrategia clasificaría todos los vasos aplicando un algoritmo de agrupamiento. La segunda divide la retina en cuatro cuadrantes y clasifica los vasos que pertenecen al mismo cuadrante independientemente del resto de los vasos. La tercera estrategia clasifica los vasos dividiendo la retina en cuadrantes que son rotados. Resultados: La mejor estrategia resultó la tercera porque minimiza el error y el número de vasos no clasificados. La característica vectorial más determinante está basada en la media o la mediana del componente gris del espacio de color RGB. Para las 20 imágenes inicialmente analizadas hemos clasificado correctamente el 86.53% de los vasos, y este porcentaje permanece similar en el grupo de 58 imágenes examinadas por tres expertos, lo que confirma la validez del método, para el cálculo del índice arteriovenoso de forma automática. Conclusión: Nuestros resultados son superiores a los descritos previamente, reduciendo además el número de vasos no clasificados. Por otro lado, el costo computacional del método es bajo


Assuntos
Humanos , Vasos Retinianos , Retinopatia Hipertensiva , Fundo de Olho , Hipertensão , Microcirculação
11.
Actas urol. esp ; 40(2): 96-101, mar. 2016. tab
Artigo em Espanhol | IBECS | ID: ibc-150719

RESUMO

Objetivo: Evaluar la persistencia terapéutica y su relación con la medicación concomitante en pacientes tratados con fesoterodina frente a tolterodina y solifenacina para el tratamiento de la vejiga hiperactiva en condiciones de práctica médica habitual. Material y métodos: Se efectuó un diseño observacional, multicéntrico, retrospectivo, realizado a partir de registros médicos de pacientes seguidos en atención primaria. Se analizaron los 3 grupos de estudio. La persistencia se definió como el tiempo (meses), sin abandono del tratamiento inicial o sin cambio a otra medicación al menos 30 días después de la prescripción inicial. La medicación concomitante fue: antidepresivos, ansiolíticos/hipnóticos, antibióticos, antisépticos, laxantes y productos-dermatológicos. Se utilizó el programa SPSSWIN versión 17 (significación estadística: p < 0,05). Resultados: Se seleccionaron para el estudio 3.094 pacientes. La media de edad fue de 54,0 años y el 62,2% fueron mujeres. Los pacientes tratados con fesoterodina mostraron mayor persistencia al tratamiento (12 meses) en comparación con solifenacina y tolterodina (40,2% frente al 34,7% y 33,6%; p = 0,008), respectivamente. Además, también mostraron un menor uso de medicación concomitante (1,1 frente a 1,2 y 1,2 fármacos; porcentajes: 61,6% frente a 67,1% y 70,1%; p < 0,03). Conclusiones: Los pacientes en tratamiento con fesoterodina frente a solifenacina y tolterodina para la vejiga hiperactiva se asociaron a una mayor persistencia al tratamiento, con una reducción de la medicación concomitante


Objective: To assess therapeutic persistence and its relationship with concomitant medication in patients treated with fesoterodine versus tolterodine and solifenacin for overactive bladder (OAB) in standard clinical practice conditions. Material and methods: An observational, multicentre retrospective study was performed based on medical registries of patients followed-up in primary care (PC). Three study groups were analysed. Persistence was defined as the time (in months) without withdrawing from the initial therapy or without changing to another medication for at least 30 days after the initial prescription. The concomitant medications were antidepressants, anxiolytic/hypnotic agents, antibiotics, antiseptic agents, laxatives and skin products. We employed the SPSSWIN program version 17 (statistical significance, P < .05). Results: We selected 3094 patients for the study. The median age was 54.0 years and 62.2% were women. The patients treated with fesoterodine shown greater treatment persistence (12 months) when compared with those who took solifenacin and tolterodine (40.2% vs. 34.7% and 33.6%, respectively; P = .008). They also showed a lower use of concomitant medication (1.1 vs. 1.2 and 1.2 drugs, respectively; percentages: 61.6% vs. 67.1% and 70.1%, respectively; P < .03). Conclusions: The patients undergoing OAB treatment with fesoterodine, when compared with those taking solifenacin and tolterodine, were associated with greater treatment persistence and a reduced use of concomitant medication


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Bexiga Urinária Hiperativa/tratamento farmacológico , Compostos Benzidrílicos/uso terapêutico , Adesão à Medicação/estatística & dados numéricos , Antagonistas Muscarínicos/uso terapêutico , Succinato de Solifenacina/uso terapêutico , Tartarato de Tolterodina/uso terapêutico , Estudo Observacional , Atenção Primária à Saúde , Estudos Retrospectivos
12.
Actas Urol Esp ; 40(2): 96-101, 2016 Mar.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-26556482

RESUMO

OBJECTIVE: To assess therapeutic persistence and its relationship with concomitant medication in patients treated with fesoterodine versus tolterodine and solifenacin for overactive bladder (OAB) in standard clinical practice conditions. MATERIAL AND METHODS: An observational, multicentre retrospective study was performed based on medical registries of patients followed-up in primary care (PC). Three study groups were analysed. Persistence was defined as the time (in months) without withdrawing from the initial therapy or without changing to another medication for at least 30 days after the initial prescription. The concomitant medications were antidepressants, anxiolytic/hypnotic agents, antibiotics, antiseptic agents, laxatives and skin products. We employed the SPSSWIN program version 17 (statistical significance, P<.05). RESULTS: We selected 3094 patients for the study. The median age was 54.0 years and 62.2% were women. The patients treated with fesoterodine shown greater treatment persistence (12 months) when compared with those who took solifenacin and tolterodine (40.2% vs. 34.7% and 33.6%, respectively; P=.008). They also showed a lower use of concomitant medication (1.1 vs. 1.2 and 1.2 drugs, respectively; percentages: 61.6% vs. 67.1% and 70.1%, respectively; P<.03). CONCLUSIONS: The patients undergoing OAB treatment with fesoterodine, when compared with those taking solifenacin and tolterodine, were associated with greater treatment persistence and a reduced use of concomitant medication.


Assuntos
Compostos Benzidrílicos/uso terapêutico , Adesão à Medicação/estatística & dados numéricos , Antagonistas Muscarínicos/uso terapêutico , Succinato de Solifenacina/uso terapêutico , Tartarato de Tolterodina/uso terapêutico , Bexiga Urinária Hiperativa/tratamento farmacológico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Atenção Primária à Saúde , Estudos Retrospectivos
13.
Stud Health Technol Inform ; 207: 55-64, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-25488211

RESUMO

The tortuosity of a vessel, that is, how many times a vessel curves, and how these turns are, is an important value for the diagnosis of certain diseases. Clinicians analyze fundus images manually in order to estimate it, but there is many drawbacks as it is a tedious, time-consuming and subjective work. Thus, automatic image processing methods become a necessity, as they make possible the efficient computation of objective parameters. In this paper we will discuss Sirius (System for the Integration of Retinal Images Understanding Service), a web-based application that enables the storage and treatment of various types of diagnostic tests and, more specifically, its tortuosity calculation module.


Assuntos
Angiofluoresceinografia/métodos , Interpretação de Imagem Assistida por Computador/métodos , Reconhecimento Automatizado de Padrão/métodos , Doenças Retinianas/diagnóstico por imagem , Vasos Retinianos/diagnóstico por imagem , Retinoscopia/métodos , Algoritmos , Humanos , Aumento da Imagem/métodos , Reprodutibilidade dos Testes , Doenças Retinianas/patologia , Vasos Retinianos/anatomia & histologia , Sensibilidade e Especificidade
14.
Med. intensiva (Madr., Ed. impr.) ; 38(5): 297-304, jun.-jul. 2014. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-126396

RESUMO

Para asegurar que el riesgo asistencial se gestiona de manera efectiva es necesario utilizar métodos sistemáticos y estructurados. La Norma española UNE 179003:2013 ofrece a las organizaciones sanitarias un marco y una forma sistemática de abordar la gestión de la seguridad del paciente desde una perspectiva clínica y organizativa, que contribuye a alcanzar un balance eficiente entre riesgo, resultados en salud y costes. Obtener la certificación con UNE 179003:2013 demuestra el cumplimiento de unas normas y unos procedimientos de trabajo dirigidos a disminuir la incidencia de eventos adversos, y obliga a realizar intervenciones de mejora continua, porque la Norma exige realizar un seguimiento periódico del sistema de gestión de riesgos mediante auditorias regulares. El objetivo de este trabajo es presentar el proceso realizado para obtener la certificación por la Norma UNE 179003:2013 en nuestro Servicio de Medicina Intensiva, proponer un programa de gestión de riesgos del paciente crítico y hacer algunas recomendaciones sobre su implantación


Systematic and structured methods must be used to ensure that healthcare risks are effectively managed. Spanish standard UNE 179003:2013 provides healthcare organizations with a framework and a systematic protocol for managing patient safety from a clinical and organizational perspective. Furthermore, it is useful in securing an efficient balance among health risk, health outcomes and costs. The UNE 179003:2013 certifies that a clinical service complies with rules and operating procedures aimed at reducing the incidence of adverse events. It also requires mandatory continuous improvement, given that the standard entails frequent monitoring of the risk management system through periodic audits. The aims of this paper are to describe the UNE 179003:2013 certification process in an Intensive Care Unit, propose a risk management program for critical patients, and offer some recommendations regarding its implementation


Assuntos
Humanos , Segurança do Paciente , Gestão da Segurança , Acreditação Hospitalar , Cuidados Críticos/métodos , Unidades de Terapia Intensiva/estatística & dados numéricos , Estado Terminal , Medição de Risco/normas
15.
Environ Res ; 132: 190-6, 2014 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-24792416

RESUMO

INTRODUCTION: Blood pressure increases in cold periods, but its implications on prevalence of hypertension and on individual progression to hypertension remain unclear. Our aim was to develop a pre-screening test for identifying candidates to suffer hypertension only in cold months among non-hypertensive subjects. METHODS: We included 95,277 subjects registered on a primary care database from Girona (Catalonia, Spain), with ≥ 3 blood pressure measures recorded between 2003 and 2009 and distributed in both cold (October-March) and warm (April-September) periods. We defined four blood pressure patterns depending on the presence of hypertension through these periods. A Cox model determined the risk to develop vascular events associated with blood pressure patterns. A logistic regression distinguished those nonhypertensive individuals who are more prone to suffer cold-induced hypertension. Validity was assessed on the basis of calibration (using Brier score) and discrimination (using the area under the receiver operating characteristics). RESULTS: In cold months, the mean systolic blood pressure increased by 3.3 ± 0.1 mmHg and prevalence of hypertension increased by 8.2%. Cold-induced hypertension patients were at higher vascular events risk (Hazard ratio=1.44 [95% Confidence interval 1.15-1.81]), than nonhypertensive individuals. We identified age, diabetes, body mass index and prehypertension as the major contributing factors to cold-induced hypertension onset. DISCUSSION: Hypertension follows a seasonal pattern in some individuals. We recommend screening for hypertension during the cold months, at least in those nonhypertensive individuals identified as cold-induced hypertensive by this assessment tool.


Assuntos
Pressão Sanguínea , Temperatura Baixa/efeitos adversos , Hipertensão/epidemiologia , Estações do Ano , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Hipertensão/etiologia , Modelos Logísticos , Masculino , Programas de Rastreamento , Pessoa de Meia-Idade , Prevalência , Modelos de Riscos Proporcionais , Medição de Risco , Adulto Jovem
16.
Med Intensiva ; 38(5): 297-304, 2014.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-24315791

RESUMO

Systematic and structured methods must be used to ensure that healthcare risks are effectively managed. Spanish standard UNE 179003:2013 provides healthcare organizations with a framework and a systematic protocol for managing patient safety from a clinical and organizational perspective. Furthermore, it is useful in securing an efficient balance among health risk, health outcomes and costs. The UNE 179003:2013 certifies that a clinical service complies with rules and operating procedures aimed at reducing the incidence of adverse events. It also requires mandatory continuous improvement, given that the standard entails frequent monitoring of the risk management system through periodic audits. The aims of this paper are to describe the UNE 179003:2013 certification process in an Intensive Care Unit, propose a risk management program for critical patients, and offer some recommendations regarding its implementation.


Assuntos
Certificação , Unidades de Terapia Intensiva/normas , Segurança do Paciente/normas , Gestão de Riscos , Humanos
18.
Hipertens. riesgo vasc ; 27(4): 154-161, jul. -ago. 2010. ilus, tab
Artigo em Espanhol | IBECS | ID: ibc-89393

RESUMO

ResumenNumerosos fármacos pueden dificultar el control de la hipertensión arterial (HTA), entre ellos los antiinflamatorios no esteroideos. Recientemente, algunos estudios de cohortes, han sugerido que el paracetamol también puede interferir en este control. Además, es bien conocida la relación entre el consumo de sal y la HTA.ResumenPor otro lado, surge la duda para el clínico de si las formulaciones solubles de paracetamol, cada vez más presentes en la farmacopea y que consiguen la solubilidad mediante sales que contienen sodio, pueden tener algún efecto sobre la presión arterial. El objetivo de este trabajo es revisar la relación entre el consumo de sal y la HTA, así como analizar las evidencias existentes sobre el efecto que puede tener el consumo de paracetamol en la HTA y si las sales de los compuestos solubles inciden sobre dicho control (AU)


AbstractThere are many medications that may complicate control of high blood pressure (HBP), among them non-steroidal anti-inflammatory drugs. Recently, some cohort studies have suggested that paracetamol (acetaminophen) can also interfere in this control. The relationship between salt consumption and HBP is also well known.AbstractFurthermore, the question also arises for the clinicians about whether soluble formulations of acetaminophen, which are increasingly more present in the pharmacopoeia and that achieve solubility through salts that contain sodium, may have some effect on blood pressure. This study has aimed to review the relationship between salt consumption and HBP and to analyze the existing evidence on the effect that acetaminophen may have on HBP and whether the salts of the soluble compounds have any impact on such control (AU)


Assuntos
Humanos , Acetaminofen/farmacocinética , Pressão Sanguínea , Hipertensão/diagnóstico , Anti-Inflamatórios não Esteroides/farmacocinética , Sódio/efeitos adversos , Determinação da Pressão Arterial/normas
19.
Med. intensiva (Madr., Ed. impr.) ; 34(3): 161-169, abr. 2010. tab, graf
Artigo em Espanhol | IBECS | ID: ibc-135990

RESUMO

Objetivo: Definir los factores pronósticos en relación con la mortalidad de los pacientes que tienen una parada cardiorrespiratoria (PCR) hospitalaria, ajustándose al estilo Utstein. Diseño: Registro descriptivo y prospectivo durante un período de 30 meses de los pacientes que tuvieron un episodio de PCR hospitalaria. Análisis multivariante mediante regresión de Cox para identificar los factores independientes asociados a la mortalidad. Ámbito: Hospitalario, Hospital General del Complejo Universitario Virgen de las Nieves. Pacientes: Todos los pacientes atendidos por una PCR en el hospital, excepto las ocurridas en las áreas de quirófanos y reanimación. Seguimiento hasta el alta hospitalaria, sin pérdidas. Variable de principal interés: mortalidad al alta hospitalaria. Resultados: Se registraron 203 pacientes que tuvieron al menos una PCR en el hospital, de los cuales el 60,6% fueron hombres (123 pacientes) con una mediana de edad de 67 años. La localización más frecuente fue en la unidad de medicina intensiva (48%) y el origen fue cardiológico (62%). Se obtuvo una supervivencia hospitalaria del 23,15%. En el análisis multivariante los factores independientemente asociados a la mortalidad hospitalaria fueron el uso de adrenalina (hazard ratio [HR]: 3,4; IC del 95%: 1,6-7), la duración total de la reanimación (HR: 1,018; IC del 95%: 1,012-1,024) y, como protectores, el primer ritmo en fibrilación ventricular/taquicardia ventricular sin pulso (HR: 0,6; IC del 95%: 0,4-0,9) y la presencia de un testigo médico (HR: 0,6; IC del 95%: 0,5-0,9). Conclusiones: Entre los factores asociados a la mortalidad tras un episodio de PCR hospitalaria se identificó el tipo de testigo. La relevancia de este hecho radica en que la cualificación del personal sanitario es un factor modificable mediante el entrenamiento adecuado (AU)


Objective: To define the prognostic factors related with mortality of patients who suffer cardiorespiratory arrest (CRA) in the hospital, according to Utstein style guidelines. Design: A descriptive and prospective study covering a 30-month consecutive period of all the patients who suffered at least one episode of in-hospital CRA. A Cox regression multivariate analysis was made to identify the independent factors associated with mortality. Setting: A medical-surgical center in Hospital «Virgen de las Nieves» (HUVN), Granada (Spain). Patients: All the patients attended due to CRA in the hospital, except for those occurring in the operating and recovery room areas. They were followed-up to hospital discharge. Main variables: Mortality on hospital discharge. Results: 203 patients who suffered at least one cardiorespiratory arrest in the hospital, with a median age of 67 years and preponderance of male (60.6%). The most common location was in intensive care medicine unit (48%) and cardiac etiology (62%). Hospital survival rate was 23.15%. In multivariate analysis, strong predictors of mortality were administration of any dose of epinephrine during resuscitation maneuvers (OR 3.4; CI 95%. 1.6-7), total duration of resuscitation (HR 1.018; CI 95%, 1.012-1.024) and as protective factors the first ventricular fibrillation/ventricular tachycardia rhythm with no pulse (HR 0.6; CI 95%, 0.4-0.9) and witnessed by a doctor (HR 0.6; CI 95%, 0.5-0.9). Conclusions: The type of witness was identified among the predictors of mortality on hospital discharge after an episode of cardiac arrest. This becomes important because the qualification of healthcare personnel can be improved through adequate training (AU)


Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Parada Cardíaca/mortalidade , Hospitalização , Prognóstico , Estudos Prospectivos
20.
Med Intensiva ; 34(3): 161-9, 2010 Apr.
Artigo em Espanhol | MEDLINE | ID: mdl-20153555

RESUMO

OBJECTIVE: To define the prognostic factors related with mortality of patients who suffer cardiorespiratory arrest (CRA) in the hospital, according to Utstein style guidelines. DESIGN: A descriptive and prospective study covering a 30-month consecutive period of all the patients who suffered at least one episode of in-hospital CRA. A Cox regression multivariate analysis was made to identify the independent factors associated with mortality. SETTING: A medical-surgical center in Hospital "Virgen de las Nieves" (HUVN), Granada (Spain). PATIENTS: All the patients attended due to CRA in the hospital, except for those occurring in the operating and recovery room areas. They were followed-up to hospital discharge. MAIN VARIABLES: Mortality on hospital discharge. RESULTS: 203 patients who suffered at least one cardiorespiratory arrest in the hospital, with a median age of 67 years and preponderance of male (60.6%). The most common location was in intensive care medicine unit (48%) and cardiac etiology (62%). Hospital survival rate was 23.15%. In multivariate analysis, strong predictors of mortality were administration of any dose of epinephrine during resuscitation maneuvers (OR 3.4; CI 95%. 1.6-7), total duration of resuscitation (HR 1.018; CI 95%, 1.012-1.024) and as protective factors the first ventricular fibrillation/ventricular tachycardia rhythm with no pulse (HR 0.6; CI 95%, 0.4-0.9) and witnessed by a doctor (HR 0.6; CI 95%, 0.5-0.9). CONCLUSIONS: The type of witness was identified among the predictors of mortality on hospital discharge after an episode of cardiac arrest. This becomes important because the qualification of healthcare personnel can be improved through adequate training.


Assuntos
Parada Cardíaca/mortalidade , Hospitalização , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Prognóstico , Estudos Prospectivos
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