Functional response of the hyperthyroid patients with beta adrenoreceptor blockade to exercise.

The submaximal test of triangular type was used for studying the adaptability to exercise, on an ergometric bicycle. It was performed, starting from O W, with progressive increasing load of 10 W/min until the maximum optimum heart rate (fho) was reached. The heart rate, arterial blood pressure, electrocardiogram, CO2 output and O2 consumption. Computed O2 consumption (VO2 max, ml/kg/min, Astrand) were determined, also taking into account the subjective sensation linked to exercise, measured on a modified Borg scale. The adaptability capacity to exercise was expressed by the adaptability coefficient (AC), according to the formula: AC = W'/2 + (W'-f'). 20 hyperthyroid patients, without cardiothyreosis were examined, both before the uptake of propranolol and after, at a certain interval of time. A decrease of the exercise capacity before the treatment and its increase after it, was noticed in the hyperthyroid patients.

Evaluation criteria of the hyperthyroid patients' adaptability to effort.

The submaximal triangular-type test was used for studying the adaptive capacity, on an ergometric bicycle. It was performed continuously, starting from O W, with a load increment of 10 watts/min up to optimal maximum heart rate (fmo). The heart rate, arterial blood pressure, electrocardiogram, CO2 output and O2 consumption computed maximal O2 consumption (VO2 max, ml/kg/min) (Astrand) were predicted, also taking into consideration the subjective sensations linked to effort, measured on a modified Borg scale. The capacity to effort was expressed by the "adaptability coefficient" (AC) according to formula: AC = W' divided by 2 + (W' --f). 40 hyperthyroid patients, compared to a lot of normal thyroid subjects were examined, both at the beginning and after the treatment at certain intervals of time. A decrease of the effort capacity before the treatment and its increase after was noticed in hyperthyroid patients.

The metabolic and functional effects of thyroid hormone excess in rats.

Oral administration of thyroid powder for 21 days produces hyperglycemia, hypocholesterolemia, increase of the energetic metabolism ratio and diminishing of the anaerobic metabolism ratio. Prolonged oral administration (30--45 days) induces involution of the thyroid gland, symptoms of an aggravated thyrotoxic hepatosis, hypoglycemia, hypocholesterolemia, a significant increase of the energetic metabolism and of the anaerobic metabolism ratios.

Investigations concerning the metabolic adaptation of rats to cold.

Investigations were performed in 40 male albino rats, mean weight 150 g, fed a standard diet and subjected to the action of cold for 8 days. The histological picture of the thyroid gland indicated a hyperfunction in accordance with the increase of oxygen intake, weight loss, an increase in glycemia, lactate, pyruvate and cholesterol.

Investigations on certain blood parameters in adrenalectomized rats.

Investigations were performed in male rats weighing 120-200 g, fed a standard diet and kept at a temperature of 22 degrees C +/- 2. Of these rats 20 belonged to the control batch and 20 were subjected to bilateral adrenalectomy in one single time. Seven days following adrenalectomy natremia, potassemia and total blood cholesterol were determined, as checking parameters of the lack of the adrenal gland and the values of glycemia, lactacidemia and pyruvemia were studied, the lactate/pyruvate ratio being computed. A significant decrease in glycemia, lactacidemia and pyruvemia, as well as in the lactate/pyruvate ratio was found.