RESUMO
SUMMARY: We measured bone mass and structure using pQCT and DXA in adolescents with Type 1 diabetes and compared the results with those of healthy peers. Our results showed that diabetes is associated with reduced bone mass and smaller bones. The diabetes-associated deficits seemed to concern male adolescents more than females. INTRODUCTION: The aim of this study was to compare bone mass and structure between adolescents with type 1 diabetes and their healthy peers. METHODS: Peripheral quantitative computed tomography (pQCT) at radius and tibia, and dual-energy X-ray absorptiometry (DXA) at lumbar spine and proximal femur were performed for 48 adolescents, 26 girls and 22 boys, with type 1 diabetes, and for healthy peers matched for age, sex, body height and weight, and pubertal maturity. RESULTS: Diabetes was associated with reduced bone mineral content (BMC) and smaller bone cross-sectional size. Diabetic boys seemed to be more affected than diabetic girls. Among the boys, the mean deficit in BMC of all measured skeletal sites was more than 10%, while among the girls it was less than 5%. CONCLUSION: In conclusion, type 1 diabetes is associated with reduced BMC and appears to affect bone cross-sectional size and cortical rigidity. The diabetes-related skeletal deficits seemed to concern male adolescents more than females. Whether diabetes-related deficits would contribute to an increased risk of fractures in adulthood or later in life remains to be confirmed.
Assuntos
Densidade Óssea , Diabetes Mellitus Tipo 1/fisiopatologia , Absorciometria de Fóton , Adolescente , Antropometria/métodos , Estudos de Casos e Controles , Criança , Diabetes Mellitus Tipo 1/complicações , Diabetes Mellitus Tipo 1/patologia , Feminino , Colo do Fêmur/patologia , Colo do Fêmur/fisiopatologia , Humanos , Vértebras Lombares/patologia , Vértebras Lombares/fisiopatologia , Masculino , Osteoporose/etiologia , Osteoporose/fisiopatologia , Rádio (Anatomia)/patologia , Rádio (Anatomia)/fisiopatologia , Fatores Sexuais , Tíbia/patologia , Tíbia/fisiopatologia , Tomografia Computadorizada por Raios XAssuntos
Imunoglobulinas Intravenosas , Lúpus Eritematoso Discoide/fisiopatologia , Lúpus Eritematoso Discoide/terapia , Complicações na Gravidez/fisiopatologia , Adulto , Anti-Inflamatórios/administração & dosagem , Anticonvulsivantes/administração & dosagem , Azatioprina/administração & dosagem , Epilepsia/complicações , Feminino , Humanos , Imunossupressores/administração & dosagem , Metilprednisolona/administração & dosagem , Gravidez , Primidona/administração & dosagemRESUMO
OBJECTIVE: To examine the effect of moderate alcohol intake with a meal on glucose homeostasis in diabetic patients. RESEARCH DESIGN AND METHODS: Alcohol (1 g/kg, an aperitif before, wine during, and a drink after a meal) or an equal amount of mineral water was given during a dinner. Blood glucose and insulin concentrations were measured before, during, and after the meal until the next morning. This study was conducted at the Helsinki University Hospital Metabolic Ward and the Finnish Diabetes Association Education Center. The participants in the study included 10 type I diabetic patients treated with insulin and 16 type II diabetic patients treated with diet alone or with diet and oral drugs. In each subject, we examined hypoglycemic episodes or differences in blood glucose or serum insulin concentrations between alcohol and the control study. RESULTS: In type I diabetic patients, blood glucose and insulin concentrations were virtually identical in both studies. In type II diabetic patients, alcohol slightly enhanced the meal-induced insulin secretion resulting in lower blood glucose concentrations next morning. No hypoglycemic glucose concentrations were observed in either group after alcohol ingestion. CONCLUSIONS: Moderate alcohol intake with a meal does not lead to hypo- or hyperglycemia in diabetic patients.
