[Hepatotoxicity of cyclosporine in patients with kidney transplants]. / Ispitivanje hepatotoksicnosti ciklosporina u pacijenata sa transplantiranim bubrezima.

In this study we have analyzed the liver transaminases levels in the 15 patients after kidney transplantation. All these patients have taken immunosuppressive cyclosporine therapy. The transaminases levels were determined by using the method Bergmayer kinetic ultraviolet test on the apparatus Tehnicon-Opera. The well known fact is the liver intoxication the same as kidney intoxication, if patients take cyclosporine for a long time. The average of the grafts in these patients were 9 years (ages between 1 and 16). The liver transaminases level was normal in all of groups of patients except for one who had high liver transaminases levels. After the correction cyclosporine therapy in the patient, the liver transaminases levels were normal. There was no possibility for monitoring of cyclosporine during the war, so the patients were determining the dose of cyclosporine on their own without any consulting with doctors. The most reliable method of cyclosporine applications is its determination, every day monitoring, and dosing by monitoring, which means concentrations in the reference values.

[Serum cyclosporine levels in patients after kidney transplantation]. / Vrijednosti ciklosporina u serumu pacijenata poslije bubrezne transplantacije.

In this study we have analyzed the cyclosporine levels in patients after kidney transplantation. The cyclosporine levels are determined by using fluorescence polarization immune-assay and monoclonal whole blood test. We analyzed nine patients with transplanted kidneys who were on specific immunosuppressive cyclosporine therapy. The cyclosporine determination was performed in these patients three times in the span of 14 to 29 days. The cyclosporine levels in seven patients were in reference interval between 100 and 300 ng/ml of whole blood. In the first determination the values in two patients were out of reference interval, one value was lower, and the other one was higher then reference interval. In second determination after dose correction in patients who had lower cyclosporin level the new level was normal and the other patient cyclosporine value was lower then in the first determination, but still a little higher then reference values.

[Evaluation of monitoring the efficacy of phenobarbital as an anticonvulsant agents using the fluorescence-polarization immunoassay]. / Procjena efikasnosti monitoringa fenobarbitona kao antikonvulzivnog agensa, primjenom fluorescentno-polarizacijskog imunoeseja.

Estimation of the monitoring efficiency of Phenobarbital as anti seizure agent was performed by using fluorescence-polarization immunoassay on analyzer ABBOTT TDx. Determined values have shown that Phenobarbital monitoring is extremely important in the prevention of epileptic seizures, especially considering its ability to induce a microsomal drug-metabolizing system.