Glucose tolerance of premenopausal women after menopause due to surgical removal of ovaries.

OBJECTIVE: To evaluate the influence of the abrupt withdrawal of ovarian function on glucose tolerance by studying premenopausal women before and after oophorectomy. METHODS: Thirty premenopausal women who needed hysterectomy for benign reasons volunteered for the study in our hospital in Istanbul, Turkey. An oral glucose tolerance test (OGTT) was performed before surgery and 3, 6 and 12 months after surgery. Fasting glucose, fasting insulin levels and insulin/glucose indexes, HOMA indexes, insulin and glucose levels were measured during OGTT. RESULTS: The mean fasting and 2-h glucose levels of the women did not change significantly during the 12 months of follow-up. However, the glucose levels during the glucose tolerance tests changed significantly after surgery (p<0.05). Insulin responses to the glucose tolerance test also increased significantly (p<0.005). Insulin/glucose indexes were significantly higher after surgery (p<0.005). Type 2 diabetes mellitus was detected in five women and impaired glucose tolerance was detected in 12 of the 30 patients after surgery in the 12-month period. CONCLUSION: The impairment of carbohydrate metabolism due to an abrupt decrease in natural estrogen levels should be considered before removing the ovaries during hysterectomy in premenopausal patients.

Psychological factors of hyperemesis gravidarum by using the SCL-90-R questionnaire.

BACKGROUND: Hyperemesis gravidarum is known as a complex disease with interaction of biological, psychological and sociocultural factors. Our study was an attempt to understand the psychological effects on hyperemesis gravidarum by using an objective scale. METHODS: Thirty-four pregnant women with hyperemesis gravidarum who were hospitalized in the Obstetrics and Gynecology Department of Dr. Lutfi Kirdar Kartal Education and Research Hospital in Istanbul, Turkey comprised the patient group and asymptomatic pregnant women who came for routine antenatal visits to our clinic were enrolled in this study as the control group between March 1, 2007 and October 15, 2008. Women in both groups filled in the Symptom Check List (SCL-90-R) questionnaire. The data collected from both groups were analyzed by using the Student's t-test (SPSS 13.00). Frequencies of high SCL scores between groups were analyzed by chi-square tests. RESULTS: The patients with hyperemesis gravidarum had higher distress scores than those in the control group. The mean value of global severity index (GSI) was 1.03 in the patient group and 0.64 in the control group. The difference was statistically significant (p < 0.005). The most significant difference between the two groups was in somatization subscales (p < 0.0001). CONCLUSION: Hyperemesis gravidarum is a complex disorder with psychological aspects. Considering this fact can help us deal with the disorder.

Chorea gravidarum: a case report.

Chorea gravidarum is a rare syndrome in pregnancy. The clinical picture is of extrapyramidal symptoms such as involuntary movements, lack of coordination and slurred speech. Neuroleptics or benzodiazepines can be used for treatment. When antiphospholipid antibodies are shown to be present, corticosteroids, and sometimes aspirin, are added to the treatment. Movement disorders can also be associated with an increased central dopamine level. In this report, we present the case of a patient with chorea gravidarum in whom an etiologic factor has not been observed. We treated the symptoms with dopamine-blocking agents such as haloperidol. We believe that, if chorea gravidarum is not accompanied by other etiologic factors (such as antiphospholipid antibodies), there is no elevated risk for the mother and the fetus.