[Pattern of mortality and pathomorphology patterns in lungs according to the materials of forensic medical examination of COVID-19 deceased (March-December 2020)]. / Struktura smertnosti i patomorfologicheskaya kharakteristika legkikh po materialam sudebno-meditsinskogo issledovaniya umershikh ot COVID-19 (mart­dekabr' 2020 g.).

The objective was to study the pattern of mortality and pathomorphological changes in lungs according to the forensic medical investigation of the corpses of the persons who died at the age of 37 to 60 years and older from COVID-19 outside healthcare facilities with no symptoms according to the catamnesis data. Eighty-nine autopsy samples taken from patients with COVID-19 confirmed by polymerase chain reaction (PCR) from the Thanatology Department of the Republican Center of Forensic Medicine for March-December 2020 were analyzed. Pathomorphological changes in the lungs corresponded to different phases of diffuse alveolar injury (DAI) development. During the exudative phase, edema, sloughing of the alveolar epithelium, presence of hyaline membranes, and thrombohemorrhagic events were predominant. In the proliferative phase, fibrin and fibrin-like deposits in alveoli, interalveolar septa thickening, excessive growth of conjunctive tissue in the interalveolar septa, pronounced fatty liver dystrophy, severe myocardium edema were observed.

[The immunomorphological characteristics of experimental bacterial sepsis]. / Immunomorfologicheskaia kharakteristika éksperimental'nogo bakterial'nogo sepsisa.

The experimental model of bacterial sepsis, based on the intraperitoneal inoculation of Staphylococcus aureus with the simultaneous suppression of sensitivity by the injection of prednisolone, has been developed in 40 guinea pigs. Sepsis is characterized by the generalization of the infection in the body and by the formation of disseminated purulent foci simultaneously with inflammatory and dystrophic changes in different organs. The development of experimental sepsis leads to an increase in the content of B lymphocytes and to the activation of humoral immunity simultaneously with the suppression of cell-mediated immunity.