Biodistribution studies of boronophenylalanine-fructose in melanoma and brain tumor patients in Argentina.

A study of the (10)B-enriched p-boronophenylalanine-fructose complex ((10)BPA-F) infusion procedure in potential BNCT patients, including four melanoma of extremities and two high-grade gliomas (glioblastoma and ganglioglioma) was performed. T/B and S/B ratios for (10)B concentrations in tumor (T), blood (B) and skin (S) were determined. The T/B ratio for the glioblastoma was in the 1.8-3.4 range. The ganglioglioma did not show any significant boron uptake. For the nodular metastasic melanoma T/B values were between 1.5 and 2.6 (average 2.1+/-0.4), corresponding to the lower limit of the mean values reported for different melanoma categories. This result might suggest a lower boron uptake for nodular metastasic melanomas. S/B was 1.5+/-0.4. An open two-compartment pharmacokinetic model was applied to predict the boron concentration during the course and at the end of a BNCT irradiation.

[Non-traumatic hypertensive rhinorrhea. Apropos of a case]. / Les rhinorrhées non traumatiques hypertensives. A propos d'un cas.

Non-traumatic C.S.F. rhinorrhea resulting from hypertensive obstructive hydrocephalus due to an intracranial tumor may constitute the presenting symptom of these affections. The authors report one case of intermittent and positional spontaneous rhinorrhea which was the only sign of a tumor in the pineal region. According to the literature and on the basis of Ommaya's classification of spontaneous rhinorrhea, we emphasize the need to distinguish between ventricular and arachnoid C.S.F leak. This different origins will determine the appropriate (ventricular or lumbar) C.S.F. shunt.