RESUMO
Phytochemical studies on an EtOH-soluble extract of the roots of Buxus sempervirens of Turkish origin have resulted in the isolation of three new steroidal alkaloids, (+)-semperviraminol (1), (+)-buxamine F (2), and (+)-17-oxocycloprotobuxine (3), along with two known steroidal alkaloids, (+)-buxoxybenzamine (4) and (+)-buxapapillinine (5). The structures of 1-3 were elucidated with the aid of spectroscopic studies. Compounds 4 and 5 exhibited phytotoxic activity against Lemna minor.
RESUMO
Four new steroidal alkaloids, (+)-cyclovirobuxeine F (1), N-benzoyl-O-acetylbuxalongifoline (2), buxasamarine (3), and (+)-cyclobuxamidine (4), along with two known steroidal bases, 16 alpha-acetoxybuxabenzamidienine (5) and trans-cyclosuffrobuxinine (6), were isolated from the leaves of Buxus longifolia. The alkaloids 1-4 showed significant antibacterial activity.
Assuntos
Alcaloides/química , Antibacterianos/isolamento & purificação , Plantas Medicinais/química , Alcaloides/isolamento & purificação , Alcaloides/farmacologia , Antibacterianos/química , Antibacterianos/farmacologia , Bactérias/efeitos dos fármacos , Sequência de Carboidratos , Cromatografia em Camada Fina , Espectroscopia de Ressonância Magnética , Testes de Sensibilidade Microbiana , Dados de Sequência Molecular , Folhas de Planta/químicaAssuntos
Anti-Hipertensivos/isolamento & purificação , Plantas Medicinais , Plantas Tóxicas , Alcaloides de Veratrum/isolamento & purificação , Veratrum/química , Animais , Anti-Hipertensivos/farmacologia , Feminino , Espectroscopia de Ressonância Magnética , Masculino , Estrutura Molecular , Ratos , Ratos Wistar , Alcaloides de Veratrum/farmacologiaRESUMO
BUXUS SEMPERVIRENS (Buxaceae) of Turkish origin has yielded a new steroidal alkaloid, (-)-( Z)-buxenone ( 1) along with its known isomer (-)-( E)-buxenone ( 2). The plant also yielded 4',5-dihydroxy-3,3',6,7-tetramethoxyflavone ( 3) and artemetin (5-hydroxy-3,3',4',6,7-pentamethoxyflavone) ( 4). These flavones have not been isolated from BUXUS species previously.