[Role of mineral elements in the immunological effects, activation nuclear transcription factor of NF-kappaB and matrix metalloproteinase].

Today chemical elements draw to themselves the increasing attention the immunological effects performance of a role of activators and inhibitors some many enzymes, active participation in inflammation processes that, undoubtedly, assumes their participation in cellular and humoral immunity. Main objective of the present review was attempt to consider a role and value of chemical elements in maintenance of a microelement homeostasis, interaction with immune system, their value in system proteolysis and regulation of antineoplastic immunity. The special attention of researchers is involved with the questions connected with ability of immune system to perceive and process pathogens with participation nuclear transcription of the factor NF-kappaB.

[Laboratory monitoring of the aspirate in transurethral drainage of the prostate in patients with chronic obstructive prostatitis]. / Laboratornyi monitoring aspirata pri transuretral'nom drenirovanii predstatel'noi zhelezy u bol'nykh khronicheskim obstruktivnym prostatitom.

Specimens obtained by aspiration at transurethral vacuum drainage of the prostate from 166 patients with obstructive prostatitis were studied before and during treatment. This study showed that the obstruction was primarily caused by epithelial and purulent "plugs" of the lobular excretory ducts. Stages of their formation and drainage technique were specified. Aspiration specimens examination was essential for diagnosis of prostatic obstruction degree in chronic prostatitis as well as for decision making on the end of the drainage therapy.

[The characteristics of the slow electrical activity of the brain in those who worked in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station]. / Osobennosti medlennoi élektricheskoi aktivnosti golovnogo mozga u likvidatorov posledstvii avarii na Chernobyl'skoi AES.

We studied the slow electrical activity of the brain in people subjected to irradiation as a result of the Chernobyl accident and in healthy donors. The mean constant potential, which is an index of energy metabolism in different regions of the cerebral cortex, is reliably lower in eliminators, as compared to the donors, thus suggesting a postradiation energy deficiency of the brain. The structure of correlations between the constant potential indices is different: the number of significant correlations in the group of eliminators is lower by 30% than in the group of donors, thus suggesting disturbed intercentral relations in the CNS under the conditions of postradiation energy deficiency of the brain.

[Activity of the autoimmune process during systemic rheumatic diseases and distribution of constant brain potential]. / Aktivnost' autoimmunnogo protsessa pri sistemnykh revmaticheskikh zabolevaniiakh i raspredelenie postoiannogo potentsiala golovnogo mozga.

The data obtained upon examination of patients with systemic rheumatic diseases were analyzed by the methods of multiple regression and step-by-step discriminant analysis. Is was shown that the activity of autoimmune process correlates with the parameters of distribution of constant potential level in the brain of each patient, irrespective of diagnosis. The scatter of potential values was the most important predictor of activity. An increase in the activity of the autoimmune process correlated with a decrease in the scatter of potential values at recording points; the cerebral cortex became equipotential.

[Constant brain potentials as neurophysiological markers of autoimmune process]. / Postoiannye potentsialy golovnogo mozga kak neirofiziologicheskie markery autoimmunnogo protsessa.

Neuroimmune interactions in systemic rheumatic diseases were studied. The state of the central nervous system was assessed from the parameters of constant brain potentials, and the state of the immune system, from a complex of immunobiochemical parameters. The highest multiple correlation coefficients were revealed between the immunobiochemical parameters and the parameters of the constant brain potential, which characterize linear and standard deviations of potentials in temporal zones from potentials at other points of recording. The results are discussed in terms of structural and functional integration of the immune and nervous systems.

[Physical criteria of pathological processes. III. Structure of the correlation between the level of steady brain potential with serum complement proteins in rheumatic diseases]. / Fizicheskie kriterii patologicheskikh protsessov. III. Struktura korreliatsionnoi urovnia postoiannogo potentsiala golovnogo mozga s belkami syvorotochnogo komplementa pri revmaticheskikh zabolevaniiakh.

The activity of serum complement proteins and the level of steady brain potential in patients with systemic lupus erythematosus and rheumatoid arthritis were determined. The statistical analysis indicated that there is a correlation between the parameters of the complement system and neurophysiological characteristics. The differences between rheumatoid arthritis and systemic lupus erythematosus are observed in the mean values of activity of complement proteins and the steady potential, their dispersions, and the structure of correlations between immunological and neurophysiological parameters.

[Physical criteria of pathological processes. II. Modulating role of functional interhemisphere asymmetry in forming and immune response in rheumatic diseases]. / Fizicheskie kriterii patologicheskikh protsessov. II. Moduliruiushchaia rol' funktsional'noi mezhpolusharnoi asimmetrii v formirovanii immunnogo otveta pri revmaticheskikh zabolevaniiakh.

The level of the brain permanent potential as a physiological criterion of the functional interhemisphere asymmetry, as well as immunological and biochemical characteristics of peripheral blood in patients with systemic rheumatic diseases were studied. It was found that the distribution of the characteristics of immune response in patients with different types of interhemisphere asymmetry. Significant differences were observed for average values of biochemical and immunological characteristics, their dispersions, as well as for the structure of relationships between the type of the interhemisphere asymmetry and immunobiochemical characteristics.

[The late sequelae of the action of irradiation during the cleanup of the aftermath of the Chernobyl catastrophe on the concentration of macro- and microelements in human blood serum]. / Otdalennye posledstviia deistviia oblucheniia pri likvidatsii posledstvii Chernobyl'skoi katastrofy na kontsentratsiiu makro- i mikroélementov v syvorotke krovi cheloveka.

The content of Cu, Fe, Zn, Mg, P, and S in the blood serum and its ultrafiltrate was studied by the inductively coupled argon plasma atomic emission spectrometry in eliminators of the accident at the Chernobyl Nuclear Power Station who worked in the accident zone in 1986-1987. Changes in the mineral equilibrium of the blood serum was expressed in elevated concentrations of the ultrafiltered Cu and S, increased Mg content in the serum, and decreased content of ultrafiltered Zn. The Fe concentration in the serum and ultrafiltrate did not differ from the control indices, thus suggesting balanced Fe transport, accumulation, and mobilization at a remote time after the radiation injury.