[Extrarenal purification in severe salicylate poisoning in adults]. / L'épuration extra-rénale dans les intoxications salicylées graves de l'adulte.

About a new case of severe salicylate intoxication, the authors wanted to confirm the advantages of extrarenal epuration in some circumstances. Besides of usual treatments, it decreases the severity of this intoxication and the delay in its treatment by reducing quickly blood salicylate level to a moderate or benign rate whose prognosis is really better. Of course, the choice among the most common treatments (hemodialysis, hemoperfusion, peritoneal dialysis) depends with technical disposals, but hemodialysis seems the most efficient with minor risks than the intoxication itself.

[Comparison of 3 high-permeability dialysers]. / Comparaison de 3 dialyseurs à haute perméabilité.

Three capillary dialyzers, with highly permeable membranes, have been compared for their capacity of epuration of blood urea nitrogen, creatinine, phosphorus, uric acid and beta 2 microglobulin, and for their respective protein losses. There were very little differences between the dialyzers for epuration of small uremic molecules, with no benefit due to high permeability membranes in comparison with conventional dialyzers. Protein losses may be important and have to be known. About beta 2 microglobulin, filtered quantities are not correlated to changes in serum levels, suggesting the presence of other mechanisms (adsorption on the membrane and generation during hemodialysis) which influence, together with epuration, perdialytic changes of serum beta 2 microglobulin concentrations.