[Value of extracorporeal radioimmunoassay in children with nephrotic syndrome]. / Znachenie ekstrakorporal'nykh radioimmunnykh issledovanii pri nefroticheskom sindrome u detei.

Extracorporeal radioimmune techniques were employed to study gonadotropic and sex hormones renin and beta 2-microglobulin in patients with nephrotic glomerulonephritis. The hypophyseal and gonadal system showed alterations which were dependent on the disease gravity. The level of renin and beta 2-microglobulin correlated first of all with renal function.

[Use of xidifon for prevention and treatment of nephropathies with metabolic disorders in children]. / Ispol'zovanie ksidifona dlia profilaktiki i lecheniia dismetabolicheskikh nefropatii u detei.

Xydofon was applied to the treatment of 68 children suffering from different renal diseases associated with metabolic disorders. The latter ones involved oxaluria (28 children), uraturia (17 children), cystinuria (14 children), and phosphaturia (9 children). To appraise the action of xydofon, use was made of the indicators of membranolysis, cellular homeostasis of calcium, lipid peroxidation, and of the level of beta 2-microglobulin in urine. The results obtained indicate that xydofon can be used as an effective remedy for the treatment of children suffering from nephropathies associated with metabolic disorders.

[The function of the hypophyseal-gonadal system in different variants of glomerulonephritis in children]. / Sostoianie gipofizarno-gonadnoi sistemy pri razlichnykh variantakh glomerulonefrita u detei.

A total of 28 children with different varieties of glomerulonephritis were examined for the pituitary-gonadal system (PGS). The examination included measurements of follicle-stimulating and luteinizing hormones, prolactin, estradiol, progesterone and testosterone. To define standards of the content of the hormones under study, 45 children of the control group were examined. The relationship was analyzed between the content of hormones and the disease activity and gravity. The most active phase of glomerulonephritis was characterized by maximal alterations in the content of pituitary and gonadal hormones. The content of the latter ones appeared to be considerably changed in patients with the mixed pattern of glomerulonephritis, attesting to profound functional derangements in the PGS. The intensity of those derangements was determined by the severity of the pathological process.

[Radioimmunologic studies of glomerulonephritis in children]. / Radioimmunologicheskie issledovaniia pri glomerulonefrite u detei.

Proceeding from a radioimmunoassay of various biologically active substances in the blood and urine (ACTH, cortisol, FSH, LH, prolactin, progesterone, estradiol, plasma renin activity and beta 2-microglobulin) of 220 children with glomerulonephritis change of all indices with relation to the type and gravity of glomerulonephritis as well as renal function was revealed. The nature of influence on corticosteroid and immunosuppressive therapy was shown. The authors consider it appropriate to use the determination of biologically active substances in the blood and urine for a more profound estimation of a child's status.