RESUMO
A complex segregation analysis of acid phosphatase activity in 50 British families showed that the essential features of the acid phosphatase polymorphism, i.e., a major gene with three alleles, is retrieved by using the biallelic mixed model. The estimates of gene frequency and displacement obtained from segregation analysis were in agreement with those obtained from electrophoretic studies. In addition, there was evidence for a multifactorial component.
Assuntos
Fosfatase Ácida/genética , Alelos , Mapeamento Cromossômico , Genética Populacional , Inglaterra , Eritrócitos/enzimologia , Humanos , Modelos Genéticos , Fenótipo , Polimorfismo GenéticoRESUMO
Forced expiratory volume in one second (FEV1.0) and forced vital capacity (FVC) were determined in 1001 healthy Nigerian school children, aged between four and 16 years. The results were analysed with respect to the ages, heights, weights and body surface areas of the subjects. Among the variables used, weight showed the best correlation with FEV1.0 in both sexes and with FVC in males. Conversely, height showed the best correlation with FVC in females. However, the differences between these correlations were not significant. The median values obtained were lower than those reported in caucasian children at all height levels, but similar to the only available data in the literature for African children. Median FEV1.0 and FVC values were higher in males than in females at most ages, particularly the younger ones. Formulae for the medians and corresponding 2.5 and 97.5% points have been produced, using either height or weight as independent variable.
Assuntos
Volume Expiratório Forçado , Capacidade Vital , Adolescente , Estatura , Peso Corporal , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Nigéria , Fatores SocioeconômicosRESUMO
Forty-four consecutive infants aged from 3 days to 10 months underwent repair of total anomalous pulmonary venous connection using deep hypothermia with circulatory arrest. There were eight (18%) early hospital deaths. Using multivariate analysis no significant association could be shown between early mortality and age or weight at operation, preoperative pulmonary or systemic pressure, and preoperative condition for patients undergoing operation during the most recent five year period. Late pulmonary venous obstruction developed in four (11%) of the survivors and all of these patients died.
Assuntos
Parada Cardíaca Induzida , Veias Pulmonares/anormalidades , Feminino , Humanos , Hipotermia Induzida , Lactente , Recém-Nascido , Masculino , Métodos , Complicações Pós-Operatórias , Prognóstico , Veias Pulmonares/cirurgiaRESUMO
A prospective 12-month survey in 272 United Kingdom hospitals was performed and data are presented on the incidence of adverse reactions following intravenous urography, contrast CT scanning, and intravenous cholangiography. Minor and intermediate reactions are commonest in young adults, but severe and fatal reactions predominate in the older age group. There is an increased risk of severe reactions in patients with a history of allergy or previous reaction to contrast media and in patients with heart disease. The risk of severe reaction is also increased in certain ethnic groups. There appears to be an association between the incidence of severe reactions and contrast medium dose. Etiology, prevention and treatment of reactions are briefly discussed.
Assuntos
Meios de Contraste/efeitos adversos , Hipersensibilidade a Drogas/epidemiologia , Hipersensibilidade Imediata/induzido quimicamente , Adolescente , Adulto , Fatores Etários , Idoso , Criança , Pré-Escolar , Colangiografia/métodos , Hipersensibilidade a Drogas/terapia , Etnicidade , Cardiopatias/complicações , Humanos , Hipersensibilidade Imediata/complicações , Hipersensibilidade Imediata/epidemiologia , Lactente , Recém-Nascido , Pessoa de Meia-Idade , Estudos Prospectivos , Tomografia Computadorizada por Raios X/métodos , Reino Unido , Urografia/métodosRESUMO
An investigation of chlamydial infection in sexual contacts of patients with nongonococcal urethritis (NGU) was carried out to determine the clinical signs of infection in the cervix, and their response to chemotherapy, and the incidence of cervical infection in the presence of ectopy and oral contraception. In 202 consecutive female contacts of NGU the isolation rate of Chlamydia trachomatis was 35%. Hypertrophic ectopy and endocervical mucopus were present in 19% and 37% of chlamydia-positive patients respectively and, in all but one, resolved after treatment. Only 14% of those followed up after treatment developed yeast infections. The chlamydial isolation rate was significantly higher in patients with hypertrophic ectopy and endocervical mucopus. Cervical ectopy and oral contraceptives acted additively, each producing a significant effect on the chlamydial isolation rate in the presence of the other but not when present alone.
Assuntos
Infecções por Chlamydia/transmissão , Uretrite/etiologia , Doenças do Colo do Útero/etiologia , Adolescente , Adulto , Colo do Útero/complicações , Colo do Útero/patologia , Infecções por Chlamydia/tratamento farmacológico , Chlamydia trachomatis/isolamento & purificação , Anticoncepcionais Orais , Eritromicina/uso terapêutico , Feminino , Humanos , Masculino , Menstruação , Pessoa de Meia-Idade , Oxitetraciclina/uso terapêutico , Gravidez , Complicações Infecciosas na Gravidez/tratamento farmacológico , Doenças do Colo do Útero/tratamento farmacológico , Doenças do Colo do Útero/microbiologia , Erosão do Colo do Útero/complicaçõesRESUMO
The purpose of this study is to investigate the relationship between preoperative signs and symptoms and the actual size of the adenoid found at operation in a group of children listed for adenoidectomy.
