[Determining acebutolol level in the blood serum]. / Oznaczanie acebutalolu w surowicy krwi.

A simple method for isolation of acebutolol from blood serum, and conditions of thin-layer chromatography for detection of this drug in blood are reported. An own colorimetric method has been developed for the determination of acebutolol after its isolation and hydrolysis in the medium of sulphuric acid. Results of the determinations were subjected to statistical analysis. The methods were elaborated using model samples prepared by addition of the acebutolol working standard to blood serum. Sensitivity of the acebutolol detection by thin-layer chromatography under elaborated conditions proved to reach the level of 0.5 microgram.