RESUMO
The distribution of iron-carbon nanoparticles in FeC-DSPE-PEG-2000 modification (micellar particles with structure (Fe) core-carbon shell; PEG-based coating) is studied. The greater part of the nanoparticles accumulated in the spleen and liver, a small amount in the lungs, and the minimum amount in the thymus. The structural changes in the lymphoid organs were minor and involved only the microcirculatory bed. Analysis of the peripheral blood showed manifest anemia, thrombocytopenia, and leukocytosis.
Assuntos
Carbono/farmacocinética , Portadores de Fármacos/farmacocinética , Ferro/farmacocinética , Nanopartículas de Magnetita/química , Animais , Carbono/metabolismo , Amarelo de Eosina-(YS) , Hematoxilina , Histocitoquímica , Ferro/metabolismo , Fígado/efeitos dos fármacos , Fígado/ultraestrutura , Pulmão/efeitos dos fármacos , Pulmão/ultraestrutura , Fosfatidiletanolaminas/química , Polietilenoglicóis/química , Ratos , Ratos Wistar , Baço/efeitos dos fármacos , Baço/ultraestrutura , Timo/efeitos dos fármacos , Timo/ultraestrutura , Distribuição TecidualRESUMO
Experiments on laboratory rats have shown the feasibility of autoplastic repair of urinary bladder wall defects using a connective-tissue capsule formed as the result of an inflammatory response to the presence of a foreign body. The formation of connective tissue prosthesis is characterized by developing fibrous connective tissue, ordering of collagen fibers, reducing the number of cells per unit area with a predominance of more mature cells - fibroblasts. With increasing time of observation, connective tissue prostheses were found to acquire a morphological structure similar to that of the urinary bladder wall. By month 12, the mucosa, the longitudinal and circular muscle layers were formed. The proposed method of partial autoplastic repair of urinary bladder wall is promising, has good long-term results, but requires further experimental studies.
Assuntos
Bioprótese , Tecido Conjuntivo/transplante , Procedimentos de Cirurgia Plástica , Bexiga Urinária/cirurgia , Procedimentos Cirúrgicos Urológicos , Animais , Implantação de Prótese , RatosRESUMO
The possibility of formation of connective-tissue vascular prostheses on subcutaneously implanted polychlorovynil base was demonstrated in experiments on rats. Suppression of the function of phagocytic cell with carrageenan decelerates, while its stimulation with tamerit accelerates the formation of connective-tissue autoprostheses.
Assuntos
Angioplastia/métodos , Prótese Vascular , Leucócitos Mononucleares/fisiologia , Fagócitos/fisiologia , Animais , Materiais Biocompatíveis/química , Carragenina/química , Fagocitose , Ratos , Fatores de TempoRESUMO
Method of transplantation of hemopoietic cells is proposed for acceleration of recovery of damaged tissue structures. The morphogenetic effect of transplantation depended on the state of damaged tissue and was determined by not only hemopoietic stem cells, but also lymphocytes, macrophages, and mast cells.
