Assuntos
Acne Vulgar/epidemiologia , Hirsutismo/epidemiologia , Síndrome do Ovário Policístico/epidemiologia , Doenças da Glândula Tireoide/epidemiologia , Adolescente , Adulto , Fatores Etários , Alopecia/epidemiologia , Comorbidade , Estudos Transversais , Feminino , Grécia/epidemiologia , Humanos , Distúrbios Menstruais/epidemiologia , Índice de Gravidade de Doença , Adulto JovemAssuntos
Acne Vulgar/etiologia , Percepção , Adolescente , Adulto , Estudos Transversais , Feminino , Humanos , Masculino , Adulto JovemRESUMO
BACKGROUND: Limited data exist on the use of systemic antibiotic treatment for hidradenitis supportive (HS). AIM: To investigate the effectiveness, safety and relapse rate of HS treated with a combination of daily oral clindamycin and rifampicin. METHODS: This was a prospective, hospital-based study of oral clindamycin 600 mg and rifampicin 600 mg daily for 12 weeks for treatment of HS. Patients were followed up for 1 year to monitor for relapse. RESULTS: In total, 26 patients with HS received oral clindamycin and rifampicin. Most were overweight or obese (73%), and most were smokers (88%). After 12 weeks, clinical response was noted in 19 patients (73%). Response was associated only with female sex (P = 0.02), and not with body mass index, Hurley stage or lesion location. Eight patients (31%) experienced adverse events. At the 1-year follow-up, there was sustained efficacy in 7 (41%) patients, while 10 (59%) had disease relapse after a mean time of 4.2 months. CONCLUSIONS: Oral clindamycin with oral rifampicin for 12 weeks is an effective and tolerable regimen for HS.