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1.
Clin Exp Dermatol ; 34(5): e163-6, 2009 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-19094125

RESUMO

A 38-year-old woman presented with a pronounced increase in symptoms and proliferation of urticaria pigmentosa (UP) after acute psychological stress, which was quantified using the Spielberger's State-Trait Anxiety Inventory. Immunohistochemical examination of a skin biopsy from a new UP lesion showed a large number of activated mast cells expressing corticotrophin-releasing factor receptor-1 (CRF-R1) and there was high serum CRF. This is the first documented report to our knowledge of UP worsening associated with acute stress, possibly through activation of skin mast-cell CRF-R1.


Assuntos
Mastócitos/metabolismo , Receptores de Hormônio Liberador da Corticotropina/metabolismo , Pele/metabolismo , Estresse Psicológico/complicações , Urticaria Pigmentosa/etiologia , Doença Aguda , Adulto , Feminino , Humanos , Urticaria Pigmentosa/metabolismo , Urticaria Pigmentosa/patologia
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