1.
Bioorg Med Chem Lett
; 18(9): 2840-4, 2008 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18434147
RESUMO
We report here a class of thiazolidine-2,4-diones and 2-thioxothiazolidin-4-ones as potent inhibitors of the lymphoid specific tyrosine phosphatase (Lyp) identified from high throughput screens. Chemical modification by incorporating the known phosphotyrosine (pTyr) mimics led to the discovery of a salicylate-based inhibitor with submicromolar potency.