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J Infect Dis ; 225(2): 214-218, 2022 01 18.
Artigo em Inglês | MEDLINE | ID: mdl-34734257

RESUMO

Air pollution particulate matter (PM) is associated with SARS-CoV-2 infection and severity, although mechanistic studies are lacking. We tested whether airway surface liquid (ASL) from primary human airway epithelial cells is antiviral against SARS-CoV-2 and human alphacoronavirus 229E (CoV-229E) (responsible for common colds), and whether PM (urban, indoor air pollution [IAP], volcanic ash) affected ASL antiviral activity. ASL inactivated SARS-CoV-2 and CoV-229E. Independently, urban PM also decreased SARS-CoV-2 and CoV-229E infection, and IAP PM decreased CoV-229E infection. However, in combination, urban PM impaired ASL's antiviral activity against both viruses, and the same effect occurred for IAP PM and ash against SARS-CoV-2, suggesting that PM may enhance SARS-CoV-2 infection.


Assuntos
COVID-19 , Coronavirus Humano 229E , Imunidade Inata , Material Particulado/efeitos adversos , População Urbana , Antivirais/farmacologia , COVID-19/prevenção & controle , COVID-19/transmissão , Humanos , Reação em Cadeia da Polimerase , SARS-CoV-2 , Saúde da População Urbana
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