RESUMO
In this study, the fluid uptake (swelling) kinetics and disintegrant properties of gellan gum in metronidazole tablets were evaluated in both simulated gastric and intestinal fluids (SGF and SIF respectively) without enzymes. The mechanical properties as well as the disintegration and dissolution profile of the tablets were also assessed and compared with those of two standard disintegrants: maize starch and sodium starch glycolate (Primogel). Results show that, swelling was faster and higher in SIF than SGF with the minimum and maximum swelling rates of the gum being 0.365 and 6.900 mm(3)/min respectively in SGF, while the corresponding values in SIF were 0.277 and 7.600 mm(3)/min respectively. The gum was most effective as a disintegrant for metronidazole tablets at an optimum concentration of 0.2% (w/w) when incorporated extra-granularly.
Assuntos
Portadores de Fármacos/química , Metronidazol/química , Metronidazol/metabolismo , Polissacarídeos Bacterianos/química , Biomimética , Preparações de Ação Retardada/química , Preparações de Ação Retardada/metabolismo , Suco Gástrico/metabolismo , Mucosa Intestinal/metabolismo , Cinética , ComprimidosRESUMO
A 76 year old man with mycosis fungoides developed an immunoblastic sarcoma and a leukemic blood picture in the final tumor stage after 6 years, in which the disease had clinically progressed in a typical manner. The results of histological and cytochemical studies of autopsy material are presented. Based on these findings and evidence of the T cell nature of mycosis fungoides, the immunoblastic sarcoma observed in the terminal stage of this case of mycosis fungoides might be of the rare T cell type.
Assuntos
Leucemia/complicações , Linfoma não Hodgkin/patologia , Micose Fungoide/patologia , Neoplasias Cutâneas/patologia , Fosfatase Ácida/sangue , Idoso , Esterases/sangue , Humanos , Contagem de Leucócitos , Masculino , Micose Fungoide/sangue , Micose Fungoide/enzimologia , Neoplasias Cutâneas/sangue , Neoplasias Cutâneas/enzimologia , Síndrome , Linfócitos T/imunologiaRESUMO
In clinical hematology the terms "monocytic" leukemia and "reticulosis" still -require better definition and classification. By presenting the histories of eight patients and by cytology and cytochemistry it is shown that myelo-monocytic leukemias can have the course well-known for an acute leukemia, including different skin lesions, as well as that of an typical chronic granulocytic leukemia. In dermatology monocytic leukemias were considered as belonging to the entity of the so-called reticulosarcomatosis cutis. However, strict differentiation from the hiary cell leukemia is to be made today. The general term "reticuloses" has quite faulty been used formerly for classification of these last two disorders.
