RESUMO
We have found previously that the relationship between the urinary contents of alpha(1)-microglobulin (alpha(1)M) and ulinastatin (UT) in patients with mood disorder differs from that of age-matched healthy subjects. However, it has yet to be determined whether or not the difference in the relation correlates with the contents of the free forms of alpha(1)M and UT in serum and whether changes in the existing forms of alpha(1)M and UT in serum reflect the actual disease states. The relation between serum contents of the free forms of alpha(1)M and UT in 10 patients with mood disorders was different from that of 17 age-matched healthy subjects. The regression plot between scores of the Hamilton Rating Scale for Depression and ratios of the free form content to total content (F/T ratio) of UT was more informative on the depressive state than that of alpha(1)M. The F/T ratios of UT may afford a useful objective index in monitoring the diseased state of a patient with mood disorder.
Assuntos
Glicoproteínas/sangue , Glicoproteínas de Membrana/sangue , Transtornos do Humor/fisiopatologia , Inibidor da Tripsina de Soja de Kunitz , Biomarcadores/análise , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Escalas de Graduação PsiquiátricaRESUMO
With mood disorders, clinical portrayals alone do not always reflect the exact state and progress of the disease. The present study attempted to evaluate whether changes in regression slope correlating between urinary contents of alpha-1-microglobulin and ulinastatin provided objective information on the severity of mood disorders, based on our previous findings that the regression slope was more steeply inclined in patients with mood disorders than in age-matched healthy subjects. As a result, a close association between scores of the Hamilton Rating Scale for Depression and the regression slopes was found: the more inclined the slope, the greater the severity of symptoms of depression. These results suggest that changes in the slope of the regression plot correlating between urinary contents of alpha 1 M and UT may afford a useful objective index when monitoring the state of patients with mood disorders.
Assuntos
alfa-Globulinas/urina , Glicoproteínas/urina , Transtornos do Humor/diagnóstico , alfa-Globulinas/metabolismo , Biomarcadores/análise , Feminino , Glicoproteínas/metabolismo , Humanos , Pessoa de Meia-Idade , Transtornos do Humor/urina , Estudos de Amostragem , Sensibilidade e Especificidade , Índice de Gravidade de DoençaAssuntos
Circulação Cerebrovascular , Alucinações/diagnóstico por imagem , Alucinações/etiologia , Lobo Occipital/patologia , Retinose Pigmentar/complicações , Tomografia Computadorizada de Emissão de Fóton Único , Idoso , Dominância Cerebral , Feminino , Humanos , Lobo Occipital/diagnóstico por imagem , Valor Preditivo dos Testes , Síndrome , Baixa Visão , Percepção VisualRESUMO
Magnetic resonance imaging (MRI) of thigh and leg muscles was performed in a patient with alcoholic myopathy showing myalgia, hypercreatine kinasemia, and hypermyoglobinemia. High signal intensities in both T1- and T2-weighted images were widely distributed in the affected muscle groups, which most likely reflected lipid accumulation. Although he had hypermyoglobinemia, MRI and muscle biopsy did not show findings of rhabdomyolysis, such as necrosis, regeneration, and edema. We suggest that the high signal intensities in this case may have indicated "prerhabdomyolysis" related to alcohol abuse and that muscle MRI is useful in the evaluation of alcoholic myopathy, mainly predicting the onset of rhabdomyolysis.
