1.
J Org Chem
; 84(21): 14227-14240, 2019 11 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-31542931
RESUMO
The first total synthesis of (7â³R,8â³R)-, (7â³S,8â³S)-isomers of princepin (1) and (7â³R,8â³R)-, (7â³S,8â³S)-isomers of isoprincepin (2) was accomplished in a highly stereoselective manner via para quinomethide-mediated construction of the furofuran and 1,4-benzodioxane rings. Structural confirmation methods of 1 and 2 were established by CD and HPLC analysis of each diastereomers with natural products.