RESUMO
Almost from all organs, both mesenchymal stromal cells and fibroblasts can be isolated. Mesenchymal stromal cells (MSCs) are the most preferred cellular therapeutic agents with the regenerative potential, and fibroblasts are one of the most abundant cell types with the ability to maintain homeostasis. Because of the promising properties of MSCs, they have been well studied and their differentiation potentials, immunomodulatory potentials, gene expression profiles are identified. It has been observed that fibroblasts and mesenchymal stromal cells have similar morphology, gene expression patterns, surface markers, proliferation, differentiation, and immunomodulatory capacities. Thus, it is hard to distinguish these two cell types. Epigenetic signatures, i.e., methylation patterns of cells, are the only usable promising difference between them. Such significant similarities show that these two cells may be related to each other.
Assuntos
Doenças Autoimunes/terapia , Epigênese Genética , Fibroblastos/citologia , Células-Tronco Mesenquimais/citologia , Doenças do Sistema Nervoso/terapia , Dermatopatias/terapia , Antígenos CD/genética , Antígenos CD/imunologia , Doenças Autoimunes/genética , Doenças Autoimunes/imunologia , Doenças Autoimunes/patologia , Biomarcadores/metabolismo , Diferenciação Celular , Linhagem da Célula , Proliferação de Células , Terapia Baseada em Transplante de Células e Tecidos/métodos , Metilação de DNA , Fibroblastos/imunologia , Fibroblastos/transplante , Expressão Gênica , Humanos , Imunomodulação , Transplante de Células-Tronco Mesenquimais/métodos , Células-Tronco Mesenquimais/imunologia , Doenças do Sistema Nervoso/genética , Doenças do Sistema Nervoso/imunologia , Doenças do Sistema Nervoso/patologia , Dermatopatias/genética , Dermatopatias/imunologia , Dermatopatias/patologiaRESUMO
BACKGROUND: The aim of this study was to investigate the relationship between endocan levels with the presence of slow coronary flow (SCF). METHODS: In this cross-sectional study, a total of 88 patients, who admitted to our hospital, were included in this study. Of these, 53 patients with SCF and 35 patients with normal coronary flow were included in the final analysis. Coronary flow rates of all patients were determined by the Timi Frame Count (TFC) method. RESULTS: In correlation analysis, endocan levels revealed a significantly positive correlation with high sensitive C-reactive protein and corrected TFC. In multivariate logistic regression analysis, the endocan levels were found as independently associated with the presence of SCF. Finally, using a cutoff level of 2.3, endocan level predicted the presence of SCF with a sensitivity of 77.2% and specificity of 75.2%. CONCLUSION: In conclusion, our study showed that higher endocan levels were significantly and independently related to the presence of SCF.
