RESUMO
To study the peroxide homeostasis's features in atherosclerosis of common carotid artery, 75 patients suffering from an arterial hypertension in the age of 60-74 years (middle age 64.62 +/- 0.57 year) and 30 practically healthy persons of advanced age were examined. Thickness of common carotid artery, atherosclerotic plaques, parameters of lipid profile, peroxide oxidation of lipid, antioxidant system (catalase, SOD), general anti-oxidative activity of the serum were estimated.
Assuntos
Envelhecimento/metabolismo , Aterosclerose/metabolismo , Artéria Carótida Primitiva/metabolismo , Homeostase , Hipertensão/metabolismo , Peroxidação de Lipídeos , Idoso , Envelhecimento/patologia , Antioxidantes/metabolismo , Aterosclerose/complicações , Aterosclerose/diagnóstico por imagem , Aterosclerose/patologia , Artéria Carótida Primitiva/diagnóstico por imagem , Artéria Carótida Primitiva/patologia , Estudos de Casos e Controles , Homeostase/fisiologia , Humanos , Hipertensão/complicações , Hipertensão/diagnóstico por imagem , Hipertensão/patologia , Peroxidação de Lipídeos/fisiologia , Lipídeos/sangue , Malondialdeído/sangue , Pessoa de Meia-Idade , Placa Aterosclerótica/diagnóstico por imagem , Placa Aterosclerótica/patologia , Túnica Íntima/diagnóstico por imagem , Túnica Íntima/patologia , Ultrassonografia Doppler DuplaRESUMO
For the purpose of estimation of peculiarities of interrelation between endothelial dysfunction (ED) and myocardial dysfunction (MD) in elderly persons due to arterial hypertension (AH) 66 patients of elderly age with AH of II stage and 26 persons of similar age without cardiovascular diseases were examined. It is established, that development AH is accompanied by formation of a concentric hypertrophy and concentric remodelling of myocardium, diastolic and systolodiastolic myocardial dysfunction, its expressiveness is interfaced to severity of endothelial dysfunction. Progressing of ED is accompanied by infringements of lipids' metabolism, increasing of their peroxidation activity and decreasing in efficiency of anti-oxidation protection.
Assuntos
Endotélio Vascular , Insuficiência Cardíaca , Hipertensão , Fatores Etários , Idoso , Biomarcadores , Ecocardiografia Doppler , Endotélio Vascular/metabolismo , Endotélio Vascular/fisiopatologia , Insuficiência Cardíaca/diagnóstico , Insuficiência Cardíaca/metabolismo , Insuficiência Cardíaca/fisiopatologia , Humanos , Hipertensão/metabolismo , Hipertensão/fisiopatologia , Metabolismo dos Lipídeos , Peroxidação de Lipídeos , Peptídeo Natriurético Encefálico/metabolismo , Estresse Oxidativo , Fatores de Risco , Índice de Gravidade de Doença , Remodelação VentricularRESUMO
Complex investigation of the structural myocardial and common carotid artery reconstruction was held to reveal some features of hypertension in the aged. The state of lipid metabolism, parameters of the oxidant system and inflammation markers were determined in healthy people (n = 30) and patients with hypertension (n = 132) of 60-74 years old. The results were discussed according to the view that adipose tissue mass elevation may be a reason for the age-associated process of the myocardial and blood vessel reconstruction from adaptive into the pathologic one. The myocardial wall is thickened because of the cardiomyocites proliferation and carotid arterial wall because of inflammation and lipid peroxidation activation. Hydrogen peroxide and nitric oxide may be regarded as markers of the oxidative stress on the background of age dependent changes of homeostasis.
