Clinicopathological and molecular characteristics of extramedullary acute myeloid leukaemia.

AIMS: Myeloid sarcoma (MS) is a rare extramedullary neoplasm composed of immature myeloid precursor cells thought to be a unique clinical presentation of acute myeloid leukaemia (AML). Like AML, MS has a poor prognosis, but due to the rare nature of MS there are limited studies examining potential prognostic factors. We report our institutional experience, with the aim of investigating and establishing salient clinicopathological and molecular features of MS. METHODS AND RESULTS: We retrospectively examined all clinicopathological and molecular data on MS patients between 2001 and 2017 from the University of Alabama at Birmingham (UAB) electronic medical records. The UAB electronic medical records were also reviewed and compared with the literature for other potential prognostic factors. Sixty-three patients were included in the study. The median overall survival was 24 months in the group with normal karyotype and 12 months in patients with an abnormal karyotype. CONCLUSIONS: We found that an abnormal karyotype was associated with a statistically significant worse prognosis.

Pars plana vitrectomy for dystrophic calcification of a silicone intraocular lens in association with asteroid hyalosis.

UNLABELLED: We present a case in which a pars plana vitrectomy (PPV) was performed to halt the progressive dystrophic calcification of an intraocular lens (IOL) and the need for an IOL exchange. With limited follow-up, the patient's visual complaints have resolved, the dystrophic calcification of the IOL has stabilized, and good visual acuity has been retained. To our knowledge, this is the first report of a patient with progressive dystrophic calcification of silicone IOLs in association with asteroid hyalosis treated primarily with a PPV. In certain cases, PPV may be considered in patients with dystrophic calcification in association with asteroid hyalosis and may prevent the need for a late IOL exchange. FINANCIAL DISCLOSURE: Neither author has a financial or proprietary interest in any material or method mentioned.