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Background: This study aims to investigate the role of neutrophil-tolymphocyte ratio, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and systemic inflammation response index in patients with myasthenia gravis, thymomas and thymic hyperplasia and to identify the relationship between the inflammation response and disease activity. Methods: Between January 2010 and December 2018, a total of 97 patients (71 males, 26 females; mean age: 36.7±16.3 years; range, 15 to 76 years) who underwent extended thymectomy with the diagnosis of myasthenia gravis were retrospectively analyzed. The patients were divided into two groups as the patient group (n=42) and the control group (n=55). Neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, monocyteto-lymphocyte ratio, and systemic inflammation response index were measured one day prior to and one month after surgery. Results: The patients with thymoma were older with a higher mean pre-systemic inflammation response index value. Preoperative systemic inflammation response index, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio were significantly higher in patients with thymoma. A preoperative systemic inflammation response index value of less than 0.62 was accepted to indicate thymic hyperplasia and a postoperative systemic inflammation response index value higher than 2.94 was indicative of thymoma. In myasthenic patients whose steroid dose was increased and/or remained the same at the first month after surgery, postoperative monocyte-to-lymphocyte ratio and systemic inflammation response index values were found to be higher compared to preoperative values (p=0.006 and p=0.032, respectively). Patients whose pyridostigmine dose was increased and/or remained the same had significantly higher systemic inflammation response index values postoperatively (p=0.029). Conclusion: The precise cut-off values of systemic inflammation response index may be helpful for the surgeon to predict the surgical outcome and post-systemic inflammation response index may be a predictive marker for estimating postoperative treatment changes.
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BACKGROUND: The aim of this study was to compare the maximum standardized uptake values on positron emission tomography/ computed tomography and survival of lung invasive adenocarcinoma subgroups. METHODS: Between January 2010 and January 2016, a total of 152 patients (112 males, 40 females; mean age: 64.2±8.6 years; range, 41 to 88 years) who underwent lung resection for an invasive adenocarcinoma were retrospectively analyzed. The patients were divided into subgroups as follows: acinar, lepidic, micropapillary, papillary, and solid. The maximum standardized uptake values in the imaging study and their relationship with survival were examined. RESULTS: There were 84 acinar (55%), 31 solid (20%), 23 lepidic (15%), nine papillary (5%), and five micropapillary (3%) cases. The positron emission tomography/computed tomography enhancement showed a statistically significant difference among the subgroups (p=0.004). The solid subgroup was the most involved (9.76), followed by micropapillary (8.98), acinar (8.06), papillary (5.82), and lepidic (4.23) subgroups, respectively. According to Tumor, Node, Metastasis staging, Stage I was present in 48.68% (n=74) of the cases, Stage II in 25.0% (n=38), Stage III in 25.0% (n=38), and Stage IV in 1.31% (n=2). The one-year, three-year, and five-year survival rates were significantly different among the disease stages (p=0.01). The longest survival duration was in the lepidic subgroup, although it did not reach statistical significance among the subgroups (p=0.587). CONCLUSION: The evaluation of invasive adenocarcinomas based on maximum standardized uptake values provides valuable information and may guide neoadjuvant and adjuvant therapies in the future.
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BACKGROUND: This study aims to investigate whether rib length to costal cartilage length ratio is effective in determining the severity of chest wall deformity. METHODS: The study included 72 patients (64 males, 8 females; mean age 18.5±6 years; range, 6 to 40 years) who were operated because of chest wall deformity and 38 control subjects (22 males, 16 females; mean age 14.6±4.2 years; range, 6 to 25 years). Of the patients, pectus excavatum was detected in 69 and pectus carinatum in three. All participants' rib length-costal cartilage length ratio index, Haller index, correction index and computed tomography depression index were measured and compared. RESULTS: In patient group, there was a mild-level significant negative relationship between computed tomography depression index and rib length-costal cartilage length ratio index (p<0.05). Except for the computed tomography depression index, there was no significant relationship between rib length-costal cartilage length ratio index and other indexes and control group indexes in patient group. Rib length was higher than costal cartilage length in patient group compared to control group. There was no statistically significant difference between patient and control groups in terms of costal cartilage length (p>0.05). CONCLUSION: Contrary to what would be expected, there was no significant difference between patient and control groups in terms of costal cartilage length. Therefore, studies with larger series are required to demonstrate if costal cartilage length is effective in determining the severity of chest wall deformities.
