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1.
Cureus ; 15(10): e46662, 2023 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-37942394

RESUMO

Background and objective The field of artificial intelligence (AI) is advancing at a rapid pace, impacting all aspects of human life. Chat Generative Pre-trained Transformer (ChatGPT), which represents one of AI's most recent and remarkable achievements, has garnered significant attention and popularity in the academic community. ChatGPT, a language model-based chatbot developed by OpenAI, responds quickly and provides answers to the questions put to it. This chatbot has the ability to gather content from a variety of sources on the internet. However, its success in providing correct information has not yet been comprehensively analyzed. In light of this, this study aimed to engage in a comparative content analysis of health-related information provided by ChatGPT and a few selected websites. Methods We performed a qualitative analysis of data obtained from various information sources by using the DISCERN score and the Journal of the American Medical Association (JAMA) benchmark criteria. In addition, readability levels of the content were measured by using the Flesch-Kincaid grade level, Gunning Fog Index, and Simple Measure of Gobbledygook (SMOG) index. Results Based on our findings, there was no statistically significant difference between the websites and ChatGPT in DISCERN scores. However, the JAMA score was statistically significantly higher for websites. With regard to the Flesch-Kincaid grade level, Gunning Fog Index, and SMOG index values, the data obtained from the websites had higher readability. Conclusion Although AI is starting to play a significant role in our everyday lives, it has yet to surpass traditional methods of accessing information in terms of readability and reliability.

2.
J Orthop Surg Res ; 18(1): 799, 2023 Oct 24.
Artigo em Inglês | MEDLINE | ID: mdl-37875891

RESUMO

OBJECTIVE: Avascular necrosis of the femoral head is a disease usually seen in middle-aged individuals. Although many aetiological factors have been blamed, there are still aetiological factors that have not been fully elucidated. Although treatment options show a wide range, early and appropriate treatment is of great importance to preserve the hip joint. In our study, we compared the results of core decompression and core decompression combined with bone marrow mesenchymal stem cell implantation in patients with avascular necrosis of the femoral head. MATERIAL METHOD: In this retrospective study, Steinberg stage 1-2 patients operated on for avascular necrosis of the femoral head between 2018 and 2023 were analysed. Separate groups were formed from patients who underwent isolated core decompression and core decompression + bone marrow mesenchymal stem cell implantation. Age, gender, Steinberg staging, aetiology of the disease, follow-up period, progression to hip arthroplasty, Vas scores, Harris hip scores (HHS), and complications were evaluated. Harris hip scores at preoperative and 2-year follow-up periods; VAS scores at preoperative, 3-month, 6-month, 1-year, and 2-year follow-up periods were analysed. RESULTS: In the study, 44 patients were analysed. While 25 patients underwent core decompression only (group 1), 19 patients underwent core decompression and bone marrow mesenchymal stem cell implantation (group 2). The mean age of the patients in group 1 was 39.3 ± 6.5 years, and the mean age of the patients in group 2 was 38.4 ± 6.7 years. The mean follow-up was 31.85 ± 4.4 months in group 1 and 32.2 ± 4.1 months in group 2. Total hip arthroplasty was performed in 2 of the patients in group 1 (one of the patients underwent total hip arthroplasty at month 28 and the other at month 33). CONCLUSION: The treatment of avascular necrosis of the femoral head varies according to various staging methods. Early diagnosis of the disease and correct treatment are very important for the patient's quality of life in the future. In our research, we found that patients who received both core decompression and stem cell implantation for early-stage avascular necrosis of the femoral head exhibited decreased pain at the 6-month, 1-year, and 2-year follow-up examinations. Additionally, their hip function improved at the 24-month mark according to the HHS evaluation.


Assuntos
Artroplastia de Quadril , Necrose da Cabeça do Fêmur , Pessoa de Meia-Idade , Humanos , Adulto , Necrose da Cabeça do Fêmur/cirurgia , Resultado do Tratamento , Cabeça do Fêmur/cirurgia , Estudos Retrospectivos , Qualidade de Vida , Descompressão Cirúrgica/métodos , Transplante de Medula Óssea/métodos
3.
Prim Care Diabetes ; 17(6): 595-599, 2023 12.
Artigo em Inglês | MEDLINE | ID: mdl-37673762

RESUMO

BACKGROUND: One of the most common chronic diseases in the elderly is diabetes. When diabetes is not well controlled, it can cause complications and affect health-related quality of life. Determining the burden of diabetes in elderly patients can provide a good health-related quality of life. AIM: The study was conducted to examine the relationship between diabetes burden and health-related quality of life in elderly patients with diabetes. METHODS: This is a descriptive and correlational study of 207 patients who applied to the diabetes outpatient clinics of a private and a public hospital in Istanbul. Respondents were completed with "Personal Information Form for Elderly People", "Elderly Diabetes Burden Scale" and the "Quality of Life in the Elderly Scale". Data were analyzed by SPSS. The tests used are Kolmogorov-Smirnov, Mann-Whitney U, Kruskal Wallis and Spearman Correlation tests. RESULTS: The mean total score from the Elderly Diabetes Burden Scale was 47.13 ± 11.95 (18-88), and the mean score from the Quality of Life in the Elderly Scale was 19.36 ± 7.00. In the study, as the total diabetes burden score of the elderly patients increased, the Quality of Life in the Elderly Scale score decreased. There was a difference between the mean total score of the Elderly Diabetes Burden Scale and gender, education, living alone and using oral antidiabetic (p < 0.05). CONCLUSIONS: As a result it was determined, a negative correlation was found between the diabetes CASP-19 scale total score and the total EDBS. Determining the burden of diabetes and affecting factors in elderly is important in terms of increasing the health-related quality of life. It may be recommended to plan diabetes education programs that will reduce the burden of diabetes and increase the health-related quality of life in elderly patients.


Assuntos
Diabetes Mellitus , Qualidade de Vida , Humanos , Idoso , Estudos Transversais , Diabetes Mellitus/diagnóstico , Diabetes Mellitus/epidemiologia , Diabetes Mellitus/terapia , Hipoglicemiantes/uso terapêutico , Instituições de Assistência Ambulatorial
4.
BMC Emerg Med ; 23(1): 110, 2023 09 19.
Artigo em Inglês | MEDLINE | ID: mdl-37726669

RESUMO

INTRODUCTION: E-scooters have become increasingly popular in Turkey due to easy accessibility. In parallel with this, the number of e-scooter-related injuries has increased gradually. The aim of this study was to determine the types of e-scooter-related orthopedic injuries, to evaluate hospitalization and surgical treatments, and to investigate the loss of work of patients and the burden incurred by the healthcare system. MATERIALS AND METHODS: This retrospective multicentre study included all orthopaedic referrals, who were admitted to two major trauma departments in Diyarbakir from January 2022 to July 2022. Patient data were analyzed, including demographic characteristics, injury pattern, types of injury and subsequent treatment. RESULTS: In a total of 62 patients, 105 orthopaedic injuries were identified, comprising 72.5% males and 27.5% females, with a median age of 34.21 years. Fifty-six (90.3%) patients were riders, and six were pedestrians. All associated e-scooters were rented. There were 44 fractures (41.9% of the total recorded injuries) including 8 (12.9%) open fractures. Surgery was required by 32 patients (51.6%) and 35 (56.4%) required hospital admission leading to hospitalization of 3.7 days on average. The average job loss of working patients after injury was determined as 2.4 months. Helmet use was detected in 6.4% of the e-scooter users, but no other protective equipment was detected in any of the patients. Furthermore, 19,3% of the patients had a blood alcohol level of > 10 mg/dl. CONCLUSIONS: The injuries that may result from an e-scooter accident can have long-term hospitalization and long-term job loss in the community. This imposes a significant financial burden on the national healthcare system and adversely affects public health. There is a need for precautions to be implemented such as infrastructure organisation, increased awareness of motor vehicle riders and e-scooter riders, and increased enforcement of rule compliance including not using e scooters after alcohol consumption and the use of protective equipment.


Assuntos
Fraturas Expostas , Hospitalização , Feminino , Masculino , Humanos , Adulto , Consumo de Bebidas Alcoólicas , Concentração Alcoólica no Sangue , Dispositivos de Proteção da Cabeça
5.
J Clin Med ; 12(15)2023 Jul 26.
Artigo em Inglês | MEDLINE | ID: mdl-37568312

RESUMO

PURPOSE: Glenohumeral joint compatibility and bone morphology are among the most critical factors in shoulder stabilization. Our study investigated the effect of the bone morphological structure of the shoulder joint on anterior shoulder dislocation. METHODS: In our study, people with a history of shoulder dislocation were selected as the patient group. In the control group, patients with shoulder MRIs for any reason and no history of shoulder dislocation were included. Those who have a fracture around the shoulder, a congenital deformity in the shoulder region, arthrosis of the shoulder, those whose MRI images cannot be measured, those with Hill-Sachs lesion, connective tissue diseases (such as Ehler Danlos), who are unsure of their diagnosis, or who have incomplete and incorrect suspicious information in their patient file have been excluded. In our retrospective case-control study, glenoid width, glenoid height, glenoid's height-to-width ratio, glenoid's depth, glenoid's version, glenoid's inclination, humerus radius of curvature, glenoid radius of curvature, and bony shoulder stability ratio were measured on MRI images of the patients. The sample size for each group was determined using a power analysis method. The intra-class coefficient (ICC) assessed interobserver and intraobserver reliability. RESULTS: A total of 80 patients, 40 each in the control and patient groups, were included in the study. Glenoid width was measured as 24.27 ± 1.58 in the patient group, 25.61 ± 1.72 in the control group; glenoid height was as measured 36.49 ± 2.26 in the patient group, 36.74 ± 1.99 in the control group; height-to-width ratio was measured as 1.5 ± 0.08 in the patient group, 1.43 ± 0.05 in the control group; glenoid version was as measured -0.53 ± 1.17 in the patient group, -1.44 ± 1.1 in the control group; glenoid inclination was measured as 1.44 ± 3.93 patient group, 2.64 ± 3.81 in the control group; glenoid depth was measured as 1.69 ± 0.41 in the patient group, 2.12 ± 0.53 in the control group; humerus radius of curvature was measured as 29.70 ± 6.76 in the patient group, 24.98 ± 3.22 in the control group; glenoid axial radius of curvature was measured as 61.8 ± 13.52 in the patient group, 52.53 ± 15.69 in the control group; glenoid coronal radius of curvature was measured as 43.01 ± 7.47 in the patient group, 37.74 ± 6.89 in the control group; the bony shoulder stability ratio was measured as 0.35 ± 0.06 in the patient group and 0.44 ± 0.06 in the control group. In the statistical evaluation, the glenoid width (p < 0.001), the glenoid height/width ratio (p < 0.001), the glenoid version (p < 0.001), the depth of the glenoid cavity (p < 0.001), and the radius of curvature measurements of the humeral head (p < 0.001) and the glenoid (axial, p < 0.007; coronal, p < 0.001) were found to be significantly different. Glenoid height and inclination were similar in both groups. CONCLUSIONS: The detection of bone morphological features that constitute risk factors for shoulder dislocations plays an important role in preventing shoulder dislocations. In this way, it provides essential data on personalized rehabilitation programs and treatment selection for recurrent dislocations.

6.
BMC Musculoskelet Disord ; 24(1): 551, 2023 Jul 04.
Artigo em Inglês | MEDLINE | ID: mdl-37403025

RESUMO

BACKGROUND: Shoulder injury related to vaccine administration (SIRVA) is a rare but increasing complication after vaccination. The aim of this study was to increase awareness of post-vaccination shoulder pain and to investigate the effect of the clinical condition of the shoulder before vaccination on the loss of function that may occur after vaccination. METHODS: This prospective study included 65 patients aged > 18 years who were diagnosed with unilateral shoulder impingement and/or bursitis. The first vaccination was performed on the shoulders with rotator cuff symptoms, then the second vaccination was performed on healthy shoulders of same patients as soon as the health system allowed. Pre-vaccination MRI of the symptomatic shoulders of the patients was performed and VAS, ASES and Constant scores were evaluated. At 2 weeks after vaccination of the symptomatic shoulder, scores were reassessed. For the patients with changes in the scores, MRI was performed again and the treatment of all patients was started. A second vaccination was given to asymptomatic shoulders and the patients were recalled two weeks later and their scores were evaluated. RESULTS: After vaccination, the symptomatic shoulder of 14 patients was affected. No clinical changes were observed in the asymptomatic shoulders after vaccination. The VAS scores of the symptomatic shoulders evaluated after vaccination were significantly higher than the scores evaluated before vaccination (p = 0.001). The ASES and Constant scores of symptomatic shoulders evaluated after vaccination were significantly decreased compared to the scores evaluated before vaccination (p = 0.001). CONCLUSIONS: Exacerbation of symptoms may occur if symptomatic shoulders are vaccinated. Before vaccination, a detailed anamnesis should be taken from the patients and vaccination should be performed to the asymptomatic side.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Lesões do Manguito Rotador , Humanos , COVID-19/prevenção & controle , Vacinas contra COVID-19/efeitos adversos , Estudos Prospectivos , Manguito Rotador/diagnóstico por imagem , Lesões do Manguito Rotador/diagnóstico por imagem
7.
J Orthop Surg Res ; 18(1): 452, 2023 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-37355648

RESUMO

OBJECTIVE: There may be biomechanical changes in the adjacent hip joint after lumbosacral fusion. The literature has limited information on how these biomechanical changes may result in hip joint space. MATERIAL: METHOD: Our retrospective study examined hip joint space narrowing in patients who underwent lumbosacral fusion between 2020 and 2022. In addition, spinopelvic parameters such as sacral slope, the sagittal vertical axis, pelvic incidence, lumbar lordosis, and pelvic tilt were compared in patients who underwent short-segment (up to three levels, S group) and long-segment (4 and higher levels, L group) fusions. RESULTS: Our study found no significant relationship between spinopelvic parameters and joint space narrowing in the S and L groups. In addition, it was determined that there was more narrowing in the hip joint space in the long-segment group, and there was a positive correlation between the segment length and the narrowing in the hip joint space. CONCLUSION: After lumbosacral fusion, narrowing of the hip joint space was observed. Particularly patients with long-segment lumbosacral fusion should be followed closely regarding hip osteoarthritis risk.


Assuntos
Lordose , Osteoartrite do Quadril , Fusão Vertebral , Humanos , Osteoartrite do Quadril/diagnóstico por imagem , Osteoartrite do Quadril/etiologia , Osteoartrite do Quadril/cirurgia , Estudos Retrospectivos , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/cirurgia , Pelve , Fusão Vertebral/efeitos adversos , Vértebras Lombares/diagnóstico por imagem , Vértebras Lombares/cirurgia
8.
J Orthop Surg Res ; 18(1): 166, 2023 Mar 03.
Artigo em Inglês | MEDLINE | ID: mdl-36869361

RESUMO

OBJECTIVE: Pediatric elbow fractures are children's most common fractures. People use the internet to get information about their illnesses and also to search for treatment options. Videos uploaded to Youtube do not go through the review process. The aim of our study is to determine the quality of videos related to child elbow fractures on Youtube. MATERIAL METHOD: The study was carried out with the data obtained from the video-sharing site www.youtube.com on 01.12.2022. Pediatric elbow fractures are written in the search engine section. Information about the number of views of the videos, upload date, view rate (number of views per day), number of comments, number of likes and dislikes, duration, whether they contain animation and the publishing source were evaluated. The videos are divided into 5 groups according to their sources: medical society/non-profit organization, physician, healthrelated website, university/academic, and patient/independent user/other. The quality of the videos was evaluated using the Global Quality Scale (GQS). All videos have been evaluated by 2 researchers. RESULTS: In the study, 50 videos were included. In the statistical evaluation, no significant correlation was found between the modified discern score and GQS found by both researchers, and the number of views, the rate of views, comments, likes and dislikes, video duration and VPI. In addition, when the GQS and modified discern scores were compared according to the source of the video, it was found that the patient/independent user/other group scores were lower numerically, but there was no statistically significant difference in comparison. CONCLUSION: Most of the videos about child elbow fractures have been uploaded by healthcare professionals. Therefore, we concluded that the videos are quite informative in terms of accurate information and quality content.


Assuntos
Fraturas do Cotovelo , Articulação do Cotovelo , Fraturas Ósseas , Mídias Sociais , Criança , Humanos , Pessoal de Saúde
10.
Healthcare (Basel) ; 11(5)2023 Mar 06.
Artigo em Inglês | MEDLINE | ID: mdl-36900772

RESUMO

BACKGROUND: The aim of our study is to compare the efficacy of PRP, steroids, and autologous blood injection in patients with chronic lateral epicondylitis. METHOD: A total of 120 patients comprised our study. Three groups of 40 patients each received only one of the following: PRP, steroids, or autologous blood injections. Thereafter, VAS (visual analog scale), DASH (Disabilities of the Arm, Shoulder, and Hand), and Nirschl scores of those treated were evaluated in the second week, the fourth week, the third month, and the sixth month. RESULTS: The baseline evaluation revealed no significant change in VAS, DASH, and Nirschl scores among the three groups (p > 0.050). At the second week evaluation, patients treated with steroids showed significant improvement compared to patients treated with PRP and autologous blood (p < 0.001). The fourth-week evaluation revealed the VAS, DASH, and Nirschl scores of the patients treated with steroids to have improved more significantly than those of patients treated with PRP and autologous blood (p < 0.001). The third month, when the results of all three groups were compared, revealed similar results (p > 0.050). The sixth-month evaluation, when the results of all three groups were compared, revealed the autologous blood and PRP applications provided significantly better results than the group treated with steroids (p < 0.001). CONCLUSION: We concluded that steroid administration is effective in the short term, while PRP and autologous blood applications are more effective than steroid administration in the long term.

11.
Foot Ankle Surg ; 29(2): 128-135, 2023 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-36535844

RESUMO

BACKGROUND: The aim of this study was to compare the effectiveness of syndesmotic screw (SS) and suture button (SB) on the reduction and fixation of syndesmosis via early postoperative bilateral computed tomography (CT). METHODS: This single-center retrospective study included 76 patients aged ≥ 18 years with a unilateral syndesmosis injury. SS was applied to 40 patients and SB to 36 patients. The differences between the sides stabilized using SB or SS and the intact sides were analyzed using the parameters of tibio-fibular clear space (∆CS) and anterior or posterior sagittal translation (∆ST) depending on the orientation of the fibula. The cases in which the fibula was translocated to the posterior of the tibia after the change of ∆ST and ∆CS> 2 mm were evaluated as malreduction. Axial CT images taken from the level of syndesmosis fixation were divided into 4 zones according to the orientation angle of the implant sent from the fibula to the tibia. RESULTS: No significant difference was found in the analyses performed between total patient group with malreduction and fixation groups in terms of ∆CS and ∆ST values (p = 0.708, p = 0.289). It was observed that the fixation material was in zone 3 in 54 patients and in zone 2 in 22 patients. No significant difference was found in the analyses performed between the SS and SB groups according to the implant zone (p = 0.191). In the SS group sent from Zone 2, the malreduction rate according to the ∆ST value of syndesmosis was found to be significantly higher than in the SB group (p = 0.008, p = 0.003). CONCLUSION: When the implant is applied with the correct technique, there is no difference between SS and SB in terms of early postoperative reduction. When the SS is advanced at an inappropriate angle, it negatively affects the reduction of the fibula, while SB can better tolerate angle errors up to certain degrees due to its flexible structure. Therefore, it can be presumed that the suture button system is a more convenient method in the reduction and fixation of syndesmosis than the syndesmotic screw. LEVEL OF EVIDENCE: Level IV.


Assuntos
Parafusos Ósseos , Fixação Interna de Fraturas , Humanos , Estudos Retrospectivos , Fixação Interna de Fraturas/métodos , Fíbula/diagnóstico por imagem , Fíbula/cirurgia , Fíbula/lesões , Articulação do Tornozelo/cirurgia , Tomografia Computadorizada por Raios X , Suturas
12.
J Back Musculoskelet Rehabil ; 35(5): 1013-1019, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-35213343

RESUMO

BACKGROUND: Cervical radiculopathy is characterized by pain, numbness, tingling, and weakness, mostly in an affected extremity, reflecting compression of a nerve in the neck is compressed or irritated where it emerges from the spinal cord. Diagnosis requires a detailed anamnesis, physical examination, and imaging. Physical therapy, exercise, medical therapy, and injections are the preferred treatments, but injections into the cervical region are only indicated if conservative treatment is ineffective. OBJECTIVE: This study explored the utility of selective cervical nerve root blocks (SNRBs) performed at various levels under ultrasound guidance (USG). METHODS: We evaluated patients diagnosed with cervical radiculopathy via physical examination and magnetic resonance imaging from November 2019 to March 2020. We included those who did not respond to conservative treatment and therefore received SNRBs at various levels. Sixty-three patients were evaluated over 6 months in terms of pain, functional status, and complications. RESULTS: We retrospectively evaluated patients with cervical herniated discs who received SNRBs at various levels between C4-7 under USG. Pain and functional status improved in month 1 and was maintained until at least month 6. CONCLUSION: SNRB injections performed under USG effectively treated pain and poor functional status in selected patients. The procedure is safe (especially) for patients who do not respond to conservative treatment.


Assuntos
Bloqueio Nervoso , Radiculopatia , Vértebras Cervicais/diagnóstico por imagem , Humanos , Bloqueio Nervoso/métodos , Dor/complicações , Radiculopatia/complicações , Radiculopatia/diagnóstico por imagem , Radiculopatia/terapia , Estudos Retrospectivos , Ultrassonografia de Intervenção/métodos
13.
J Back Musculoskelet Rehabil ; 35(1): 135-139, 2022.
Artigo em Inglês | MEDLINE | ID: mdl-34151825

RESUMO

BACKGROUND: Low back pain affects 80% of people worldwide at least once in a lifetime and reduces the quality of life and causes absence from work. OBJECTIVE: To evaluate the pain and functional status of patients with lumbar disc disease who received blind caudal epidural injections (CEI) for pain relief. METHODS: The records of 107 patients who had been given CEI between September 2017 and January 2018 were retrospectively analyzed. The inclusion criteria were age > 18 years, > 3-month history of low back pain, and diagnosis of lumbar disc disease by magnetic resonance imaging. The epidural injection solution consisted of 2 mL of betamethasone sodium and 8 mL saline. Follow-up examinations were conducted 3 and 6 months post-injection and the patients were evaluated using a visual analog scale (VAS) and the Oswestry Disability Index (ODI). RESULTS: The most common disc pathology was at the L4-L5 level. The VAS and ODI scores indicated significantly reduced pain at 3 and 6 months compared with the pre-injection baseline. Two patients experienced total anesthesia and paresis of the lower limbs, but recovered fully after 2 weeks. Blood was aspirated during the injection in two patients, but second-attempt injections were successful in both cases. No other complications were observed. CONCLUSION: Our results suggest that the blind method is safe for administering CEI to patients with chronic low back pain in the absence of radiological screening and results in significant pain relief with improved functional capacity.


Assuntos
Dor Crônica , Dor Lombar , Adulto , Dor Crônica/tratamento farmacológico , Método Duplo-Cego , Humanos , Injeções Epidurais , Dor Lombar/diagnóstico por imagem , Dor Lombar/tratamento farmacológico , Vértebras Lombares/diagnóstico por imagem , Pessoa de Meia-Idade , Qualidade de Vida , Estudos Retrospectivos , Esteroides/uso terapêutico , Resultado do Tratamento
14.
J Clin Orthop Trauma ; 10(2): 290-295, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-30828196

RESUMO

INTRODUCTION: Comparison was made of the clinical and radiological results of the surgical treatments of proximal femoral nail (PFN), dynamic hip screw (DHS) or proximal femoral locking compression plate (PF-LCP) in patients with AO 31A2.2/2.3 unstable intertrochanteric femoral fracture(ITF). METHODS: Evaluation was made of a total of 91 patients in respect of age, gender, time from fracture to surgery, operating time, amount of blood replacement, total hospitalisation, follow-up period, time to full weight-bearing, time to union, complications and Harris hip scores(HHS). RESULTS: A statistically significant difference was determined between the groups in respect of perioperative operating time, blood replacement and hospitalisation period with the values of the PFN group seen to be superior to those of the other two groups (p < 0.001). No significant difference was determined beween the DHS and PFN groups in respect of time to union and in the long-term HHS, both groups were seen to be superior to the PF-LCP group (p < 0.001). Full weight-bearing was statistically significantly earlier in the PFN group (p < 0.001). The numbers of implant failures was statistically significantly higher in the PF-LCP group (p < 0.001). CONCLUSION: The new generation intra-medullar nails are easy to apply and have more successful clinical results compared to extra-medullar implants in the treatment of A2 unstable ITF. Due to the high rates of implant failure, PF-LCP should not be preferred in these fractures.

15.
J Biomed Mater Res B Appl Biomater ; 105(6): 1573-1585, 2017 08.
Artigo em Inglês | MEDLINE | ID: mdl-27126123

RESUMO

Patients with diabetes mellitus have an increased cardiovascular risk due to the abnormality of hemostatic system components. Therefore, hemostasis is an important concept when considering that diabetics are under risk due to potential bleeding complications during surgical operation. The aim of our study was to examine the efficiency of a fabricated nano/microbilayer hemostatic dressing for bleeding control in diabetic patients. For this purpose, we prepared a nano/microbilayer hemostatic dressing that has a porous sublayer, including chitosan (CTS), bacterial cellulose (BC) as basement and active agents in coagulation cascade, such as vitamin K (Vit K), protamine sulfate (PS), and kaolin (Kao) as a filler and an upper layer consisting of silk fibroin (SF) or SF/phosphatidylcholine (PC) blend to achieve complete hemostasis in diabetic rats. Coagulative performances of the prepared hemostatic dressings were examined by the determination of bleeding time, blood loss, and mortality rate through diabetic rat femoral artery injury model. The percent of diabetic rat blood absorption was found to be 247 ± 5% for gauze as opposed to 2214 ± 56% for SF-coated PS/BC/CTS. Vit K-reinforced within 138 s and SF-coated BC/CTS hemostatic dressings within 144 s showed a rapid coagulation time. In vivo coagulation studies demonstrated that hemostatic agent-reinforced BC/CTS hemostatic dressing, especially PS/BC/CTS showed a significant hemostatic plug formation. This study suggests that the high positive charge and porosity give to these hemostatic agents reinforced hemostatic dressings the ability to rapidly swell and to promote the accumulation of red blood cells and platelets through electrostatic interactions. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 1573-1585, 2017.


Assuntos
Bandagens , Artéria Femoral/lesões , Hemorragia/terapia , Hemostáticos/química , Hemostáticos/farmacologia , Animais , Celulose/química , Celulose/farmacologia , Quitosana/química , Quitosana/farmacologia , Modelos Animais de Doenças , Feminino , Fibroínas/química , Fibroínas/farmacologia , Caulim/química , Caulim/farmacologia , Protaminas/química , Protaminas/farmacologia , Ratos , Ratos Sprague-Dawley
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