Heart disease diagnosis using optimized features of hybridized ALCSOGA algorithm and LSTM classifier.

Cardiac disease is the predominant cause of global death mainly due to its hidden symptoms and late diagnosis. Hence, early detection is important to improve quality of life. Though traditional researches attempted to predict heart disease, most of them lacked with respect to accuracy. To solve this, the present study proposes a hybridized Ant Lion Crow Search Optimization Genetic Algorithm (ALCSOGA) to perform effective feature selection. This hybrid optimization encompasses Ant Lion, Crow Search and Genetic Algorithm. Ant lion algorithm determines the elite position. While, the Crow Search Algorithm utilizes the phenomenon of position and memory of each crow for evaluating the objective function. Both these algorithms are fed into Genetic Algorithm to improve the performance of feature selection process. Then, Stochastic Learning rate optimized Long Short Term Memory (LSTM) is proposed to classify the extracted optimized features. Finally, comparative analysis is performed in terms of accuracy, recall, F1-score, and precision. Moreover, statistical analysis is performed with respect to Sum of Squares (SS), degree of freedom (df), F Critical (F crit), F Statistics (F), p, and Mean Square (MS) value. Analytical results revealed the efficiency of proposed system over conventional methods and thereby confirming its efficiency for predicting heart disease.

Crystal structures of two new isocoumarin derivatives: 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one.

The title compounds, 8-amino-6-methyl-3,4-diphenyl-1H-isochromen-1-one, C22H17NO2, (I), and 8-amino-3,4-diethyl-6-methyl-1H-isochromen-1-one, C14H17NO2, (II), are new isocoumarin derivatives in which the isochromene ring systems are planar. Compound II crystallizes with two independent mol-ecules (A and B) in the asymmetric unit. In I, the two phenyl rings are inclined to each other by 56.41 (7)° and to the mean plane of the 1H-isochromene ring system by 67.64 (6) and 44.92 (6)°. In both compounds, there is an intra-molecular N-H⋯O hydrogen bond present forming an S(6) ring motif. In the crystal of I, mol-ecules are linked by N-H⋯π inter-actions, forming chains along the b-axis direction. A C-H⋯π inter-action links the chains to form layers parallel to (100). The layers are then linked by a second C-H⋯π inter-action, forming a three-dimensional structure. In the crystal of II, the two independent mol-ecules (A and B) are linked by N-H⋯O hydrogen bonds, forming -A-B-A-B- chains along the [101] direction. The chains are linked into ribbons by C-H⋯π inter-actions involving inversion-related A mol-ecules. The latter are linked by offset π-π inter-actions [inter-centroid distances vary from 3.506 (1) to 3.870 (2) Å], forming a three-dimensional structure.