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Rinsho Byori ; 54(12): 1204-8, 2006 Dec.
Artigo em Japonês | MEDLINE | ID: mdl-17265892

RESUMO

Creatinine clearance (Ccr) is generally used as a halmark of glomerular filtration rate (GFR) in clinical medicine. Recently, it has been suggested that serum cystatin C measurement in serum reflects GFR. We compared serum cystatin C, serum creatinine, and serum beta2-microgrobrin in 70 patients with renal diseases in reference to creatinine clearance. The correlation between Ccr and 1/cystatin C was higher (r = 0.830) than that between Ccr and 1/serum creatinine (r = 0.789) or 1/serum beta2-microgroburin (r = 0.732). The levels of serum cystatin C in patients with Ccr ranging from 51 to 70 ml/min were significantly higher than those in patients with Ccr ranging more than 91 ml/min. Receiver-operated characteristic (ROC) analysis revealed that serum cystatin C showed the highest area under the curve among the three when Ccr = 90 ml/min was used as the cutoff point. We conclude that serum cystatin C is more useful than serum creatinine to detect early renal dysfunction.


Assuntos
Cistatinas/sangue , Nefropatias/diagnóstico , Testes de Função Renal/métodos , Adulto , Idoso , Biomarcadores/sangue , Creatinina/sangue , Cistatina C , Diagnóstico Precoce , Feminino , Taxa de Filtração Glomerular , Humanos , Nefropatias/fisiopatologia , Masculino , Pessoa de Meia-Idade , Curva ROC , Microglobulina beta-2/sangue
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