Determine Relationship Between Xerostomia and Quality of Life of HIV Person's Living in Prison.

Aims: The objective of this study was to determine relationship between xerostomia and quality of life of HIV person's living in prison. Materials and Methods: an observational study using cross sectional design was done among 68 HIV AIDS person in prison in Jakarta, but only 54 could be analyzed because of incomplete data. We used the xerostomia inventory questionnaire to assess xerostomia, and for salivary flow rate was measured by the spitting method without stimulation. Quality of life was assessed using questionnaire of the Oral Health Impact Profile (OHIP-14). Results: Quality of life of HIV AIDS patient, only 55.6% was good. There was a significant relationship between xerostomia and quality of life with Prevalence Ratio 3.16. From 11 questions regarding xerostomia there were 4 questions that were significantly related to quality of life (P < 0.05), namely dry mouth when eating, need water when swallowing food, dry eyes, dry nose. In conclusion many HIV AIDS patient experienced xerostomia which affects their quality of life. Conclusion: Xerostomia was a risk factor of having low quality of life, it showed on Prevalence ratio in most of items of OHIP.

N-acetyltransferase 2 polymorphism and acetylation profiles in Buginese ethnics of Indonesia.

BACKGROUND: N-acetyltransferase 2 (NAT2) is a key enzyme involved in the phase II metabolism of aromatic amines and heterocyclic aromatic amines present in a wide range of xenobiotics. The aim of this study was to investigate the NAT2 polymorphism in the Buginese ethnic group of Indonesia to determine the frequency of NAT2 alleles in this population. RESULTS: We found six haplotypes consisting of six single-nucleotide polymorphisms and 12 NAT2 genotype variations. NAT2*6A haplotype (42%) showed the highest frequency, followed by NAT2*4 (33%), NAT2*7B (15%), NAT2*5B (5%), NAT2*12A (3%), and NAT2*13 (2%). In terms of phenotypes, the Buginese population comprised 18% rapid acetylators, 40% intermediate acetylators, and 42% slow acetylators. CONCLUSION: We confirmed the high-frequency slow acetylator phenotype in the Buginese population. The NAT2*6A/*6A genotype was the most frequent slow acetylator genotype, followed by NAT2*6A/*7B. The pattern of NAT2 alleles of Buginese is similar to Southeast Asian populations but not Northeast Asian populations. However, the slow acetylator frequencies in the Buginese population were higher than those in Northeast Asian populations and lower than those in Caucasians and some American populations.