Shrinkage in oral squamous cell carcinoma: An analysis of tumor and margin measurements in vivo, post-resection, and post-formalin fixation.

PURPOSE: To quantify changes in tumor size and tumor-free margins following surgical resection and formalin fixation of oral cavity squamous cell carcinoma. MATERIALS AND METHODS: Nineteen patients were studied via cohort design. Between May and December 2011, measurements of tumor size and tumor-free margin were made in patients with squamous cell carcinoma of the oral cavity. Mucosal reference points were marked with sutures, representing tumor diameter and two separate resection margins. Measurements were recorded immediately before resection, after resection, and following fixation in formalin. RESULTS: The overall mean shrinkage in tumor size was 10.7% (95% CI 3.4-18.0, p=0.006). When comparing mean tumor measurements, most of the tumor size decrease (6.4%, 95% CI 0.4-12.4, p=0.039) occurred between pre- and post-excision measurements. To a lesser extent, tumor size decreased following formalin fixation. Comparison of tumor-free margin measurements revealed a pre-excision to post-fixation mean decrease of 11.3% (95% CI 2.9-19.6%, p=0.011), with a statistically significant decrease of 14.9% (95% CI 8.5-21.3%, p<0.001) occurring between pre- and post-excision, and no significant decrease from post-excision to post-formalin fixation. CONCLUSION: Mucosal dimensions of both tumor and tumor-free margins in oral cavity squamous cell carcinoma specimens decrease between surgical resection and pathologic analysis. Most of this decrease occurs prior to fixation, especially for margins, and may be due to intrinsic tissue properties rather than formalin effects.

Pediatric Oral Electrical Burns: Incidence of Emergency Department Visits in the United States, 1997-2012.

OBJECTIVES: To investigate the epidemiology of emergency department visits for pediatric patients presenting with electrical burns to the mouth. STUDY DESIGN: Cross-sectional analysis of a national database. SETTING: National Electronic Injury Surveillance System Database. SUBJECTS AND METHODS: The Consumer Product Safety Commission's National Electronic Injury Surveillance System database was used to derive a national weighted estimate of emergency department visits for oral electrical burns and was queried for each patient's age, sex, race, local of incidence, disposition, and related consumer product. RESULTS: There were an estimated 1042 emergency department visits for pediatric oral electrical burns from 1997 to 2012, or an average of approximately 65.1 cases per year. A total of 59.6% of patients were male. Nearly half of emergency department visits involved patients <3 years of age, and more than three-fourths of emergency department visits involved patients <5 years of age. A total of 77.2% of patients were examined, treated, and released from the emergency department, while 19.2% were admitted to the hospital. Most injuries involved electrical outlets or receptacles (10.8%), extension cords (18.5%), and electrical wires (21.5%). CONCLUSION: Earlier incidence estimates of pediatric oral electrical burns varied substantially within the literature and varied from small case reports to single-year studies. Our multiyear data analysis provides evidence of decreasing annual incidence when compared with historical estimates for a common but potentially morbid injury among the pediatric population.