Machine learning approach using 18 F-FDG PET-based radiomics in differentiation of lung adenocarcinoma with bronchoalveolar distribution and infection.

OBJECTIVE: In this study, we aimed to evaluate the role of 18F-fluorodeoxyglucose PET/computerized tomography ( 18 F-FDG PET/CT)-based radiomic features in the differentiation of infection and malignancy in consolidating pulmonary lesions and to develop a prediction model based on radiomic features. MATERIAL AND METHODS: The images of 106 patients who underwent 18 F-FDG PET/CT of consolidated lesions observed in the lung between January 2015 and July 2020 were evaluated using LIFEx software. The region of interest of the lung lesions was determined and volumetric and textural features were obtained. Clinical and radiomic data were evaluated with machine learning algorithms to build a model. RESULTS: There was a significant difference in all standardized uptake value (SUV) parameters and 26 texture features between the infection and cancer groups. The features with a correlation coefficient of less than 0.7 among the significant features were determined as SUV mean , GLZLM_SZE, GLZLM_LZE, GLZLM_SZLGE and GLZLM_ZLNU. These five features were analyzed in the Waikato Environment for Knowledge Analysis program to create a model that could distinguish infection and cancer groups, and the model performance was found to be the highest with logistic regression (area under curve, 0.813; accuracy, 75.7%). The sensitivity and specificity values of the model in distinguishing cancer patients were calculated as 80.6 and 70.6%, respectively. CONCLUSIONS: In our study, we created prediction models based on radiomic analysis of 18 F-FDG PET/CT images. Texture analysis with machine learning algorithms is a noninvasive method that can be useful in the differentiation of infection and malignancy in consolidating lung lesions in the clinical setting.

The prognostic relationship of 18F-FDG PET/CT metabolic and volumetric parameters in metastatic ALK + NSCLC.

OBJECTIVE: The aim of this study is to determine the role of metabolic and volumetric parameters obtained from 18Fluorine-Fluorodeoxyglucose PET/computed tomography (18F-FDG PET/CT) imaging on progression-free survival (PFS) and overall survival (OS) in patients with advanced nonsquamous cell lung carcinoma (NSCLC) with anaplastic lymphoma kinase (ALK) rearrangement. METHODS: Pre and post-treatment PET/CT images of the ALK + NSCLC patients between January 2015 and July 2020 were evaluated. The highest standardized uptake value (SUVmax), metabolic tumor volume (MTV) and total lesion glycolysis (TLG) values were obtained from pre-tyrosine kinase inhibitor (TKI) basal PET/CT (PETpre) and post-TKI PET/CT (PETpost) images. Total MTV (tMTV) and total TLG (tTLG) values were calculated by summing MTV and TLG values in all tumor foci. The change (Δ) in pSUVmax, pMTV, pTLG, tMTV and tTLG before and after treatment was calculated.The relationship of these parameters with OS and PFS was analyzed. RESULTS: tTLGpre, tMTVpre, pTLGpre, pMTVpre, ∆SUVmax, ∆tMTV and ∆tTLG values were found to be associated with OS; ∆tMTV, ∆tTLG, tTLGpre, tMTVpre, pTLGpre and pMTVpre were associated with PFS. The cutoff values in both predicting OS and PFS were calculated as -31.6 and 391.1 for ∆tMTV and tTLGpre, respectively. In Cox regression analysis, ∆tMTV and stage for OS and ∆tMTV and tTLGpre for PFS were obtained as prognostic factors. CONCLUSIONS: Metabolic and volumetric parameters, especially TLG values in the whole body before treatment and change in whole body MTV value, obtained from PET/CT may be useful in predicting prognosis and determining treatment strategies for patients with advanced ALK + NSCLC.