RESUMO
Since December 1992 we have performed laparoscopic-assisted vaginal hysterectomy (LAVH) in 50 women using strict, conventional, basic operative rules, and compared it with open abdominal hysterectomy with respect to operation time, cost, postoperative analgesia requirements, and length of hospital stay. The indications for hysterectomy were uterine myoma in 32 patients, dysfunctional bleeding in 13, and postmenopausal bleeding in 5. The mean operating time was 118 minutes. The mean blood loss was 3.2% for preoperative and postoperative hematocrit values. The complication rate was 15%. The advantages of LAVH include short hospitalization, early recovery, low blood loss, and minimal postoperative discomfort.
Assuntos
Tubas Uterinas/cirurgia , Histerectomia Vaginal , Laparoscopia , Ovariectomia , Técnicas de Sutura , Adulto , Analgésicos Opioides/administração & dosagem , Analgésicos Opioides/uso terapêutico , Perda Sanguínea Cirúrgica , Custos e Análise de Custo , Feminino , Hematócrito , Hospitalização , Humanos , Histerectomia/efeitos adversos , Histerectomia/métodos , Histerectomia Vaginal/efeitos adversos , Histerectomia Vaginal/métodos , Complicações Intraoperatórias , Laparoscopia/efeitos adversos , Laparoscopia/métodos , Leiomioma/cirurgia , Tempo de Internação , Meperidina/administração & dosagem , Meperidina/uso terapêutico , Pessoa de Meia-Idade , Ovariectomia/efeitos adversos , Ovariectomia/métodos , Dor Pós-Operatória/tratamento farmacológico , Dor Pós-Operatória/prevenção & controle , Pós-Menopausa , Técnicas de Sutura/efeitos adversos , Fatores de Tempo , Hemorragia Uterina/cirurgia , Neoplasias Uterinas/cirurgiaRESUMO
OBJECTIVES: In this study, we evaluated the importance of the determination of serum prolactin levels in postpill amenorrheic patients. METHODS: Serum estradiol and prolactin levels were determined in 37 postpill amenorrheic patients. Bromocriptine was administered to the hyperprolactinemic group and clomiphene citrate to the normoprolactinemic group. RESULTS: Hyperprolactinemia was observed in 21 patients (56.7%) and serum estradiol levels < 50 pg/ml were found in 19 of these patients. The mean prolactin level was 71.90 +/- 23.05 ng/ml in the hyperprolactinemic group. While bromocriptine had a significant effect on the length of time for menstrual bleeding to return (P < 0.001), clomifene had no effect. CONCLUSIONS: No treatment is required for the postpill amenorrheic patients with normal estradiol and prolactin levels. If hyperprolactinemia is detected, bromocriptine may be used as a treatment to promote normal menstrual bleeding and ovulation.
Assuntos
Amenorreia/sangue , Prolactina/sangue , Adulto , Amenorreia/induzido quimicamente , Bromocriptina/farmacologia , Anticoncepcionais Orais/efeitos adversos , Estradiol/sangue , Feminino , Galactorreia/sangue , Humanos , Menstruação/efeitos dos fármacosRESUMO
The administration of 0.3-40 mg/kg delta 9-tetrahydrocannabinol (THC) produced a dose-dependent hypothermia in rats. The maximal hypothermic effect was obtained with the dose of 2.5 mg/kg of THC. When the same doses of THC were repeated on days 2 and 3, tolerance to the hypothermic effect of THC was apparent. Doses of THC higher than 2.5 mg/kg induced a significant and dose-dependent tolerance after the first administration whereas with the lower doses, tolerance was only apparent after the second injection. The possible mechanism of these effects of THC is discussed.
Assuntos
Dronabinol/farmacologia , Hipotermia/induzido quimicamente , Animais , Relação Dose-Resposta a Droga , Tolerância a Medicamentos , Masculino , RatosRESUMO
The effect of delta 9-tetrahydrocannabinol (THC) on the locomotor activity-stimulating action of morphine has been investigated in mice. THC (10 mg/kg) has been found to potentiate morphine-induced hyperactivity. On the other hand, the stimulating action of morphine on motor activity strongly diminished in mice rendered tolerant by the implantation of a morphine pellet. The pretreatment of morphine-tolerant mice with the same dose of THC did not change the effect of morphine on the motor activity. These results suggest that tolerance also developed to the potentiating action of THC on morphine-induced hyperactivity during the development of tolerance to this action of morphine.
