RESUMO
To determine hydrochlorides of butobendin, carbocromen, hexobendin, lidocaine, procainamide, todrazoline in pharmaceutical preparations, two analytical techniques were applied: the direct potentiometric method (from a standard curve) using an ion-selective chloride electrode and the method of potentiometric titration using a silver electrode as well as an ion-selective chloride electrode (indirect method). A statistical analysis has been carried out, and statistical tests were applied to compare the methods used.
Assuntos
Fármacos Cardiovasculares/análise , Fenômenos Químicos , Química , Cloretos , Eletrodos , Potenciometria , PrataRESUMO
Electronic spectra of butobendin are stable between pH 1.00 and 10.89, but they change with pH in the range 10.89-2.19, due to hydrolysis. Spectrophotometric (in aqueous solution at 212 or 270 nm) and spectrofluorometric (in 1N acetic acid, at 270/368 nm) methods of butobendin assay in tablets were elaborated and found to yield precise and reproducible results.