RESUMO
We present a case of ureterovesical stenosis that developed in 2 of 203 renal transplant patients operated between 1997 and 2005 in our department. In the current case, an ureterovesical region tumor was identified 1.5 years after renal transplantation, while being operated for the correction of ureterovesical stenosis. This report sought to remind physicians about the possibility of a malignancy in patients with ureterovesical stenosis following renal transplantation.
Assuntos
Transplante de Rim/efeitos adversos , Neoplasias Ureterais/patologia , Neoplasias da Bexiga Urinária/patologia , Adulto , Antimetabólitos Antineoplásicos/uso terapêutico , Carcinoma de Células de Transição/diagnóstico por imagem , Carcinoma de Células de Transição/tratamento farmacológico , Carcinoma de Células de Transição/patologia , Desoxicitidina/análogos & derivados , Desoxicitidina/uso terapêutico , Humanos , Incidência , Masculino , Diálise Peritoneal Ambulatorial Contínua , Radiografia , Fatores de Tempo , Neoplasias Ureterais/diagnóstico por imagem , Neoplasias Ureterais/epidemiologia , Neoplasias da Bexiga Urinária/diagnóstico por imagem , Neoplasias da Bexiga Urinária/epidemiologia , GencitabinaRESUMO
The levels of serum interleukin-1beta (IL-1beta), interleukin-2 (IL-2), tumor necrosis factor alpha (TNF-alpha) and gamma-interferon (gamma-IFN) were assessed in the workers who were occupationally exposed to lead and cadmium. The values were compared with the age-matched control group. Blood lead and cadmium levels were significantly raised. Our findings suggest that chronic lead and cadmium exposure in humans resulted in significant suppression of the serum IL-1beta level, but did not alter IL-2 and TNF-alpha levels. The gamma-IFN level was also reduced in lead workers. In contrast, a significant enhancement was observed in the cadmium-exposed group. We conclude from these results that lead and cadmium exposure at chronically high level may affect some cytokine levels in humans.
Assuntos
Cádmio/efeitos adversos , Citocinas/sangue , Indústrias Extrativas e de Processamento , Chumbo/efeitos adversos , Exposição Ocupacional/efeitos adversos , Adulto , Cádmio/sangue , Humanos , Interferon gama/sangue , Interleucina-1/sangue , Interleucina-2/sangue , Chumbo/sangue , Masculino , Pessoa de Meia-Idade , Espectrofotometria Atômica , Fator de Necrose Tumoral alfa/metabolismoRESUMO
Lead and cadmium are common environmental contaminants that alter the immune response. Natural killer cell (NK) cytotoxicity and phenotypic parameters are crucial immune responses, but little is known about the effects of these metals on these responses. In the present paper, we investigated the simultaneous effects of lead and cadmium on NK cell activity and CD4+, CD20+ cell percentages in the workers and compared the data with control and lead-exposed groups. We conclude that simultaneous exposure to lead and cadmium is not associated with an impairment of either NK cell function of CD4+ cell percentage. On the other hand, CD20+ cell percentage was found higher in lead+cadmium exposed group than controls.
Assuntos
Cádmio/efeitos adversos , Citotoxicidade Imunológica/efeitos dos fármacos , Imunofenotipagem , Células Matadoras Naturais/efeitos dos fármacos , Células Matadoras Naturais/metabolismo , Chumbo/efeitos adversos , Adulto , Antígenos CD20/análise , Antígenos CD20/efeitos dos fármacos , Contagem de Linfócito CD4/efeitos dos fármacos , Cádmio/sangue , Testes Imunológicos de Citotoxicidade , Sinergismo Farmacológico , Humanos , Células Matadoras Naturais/classificação , Chumbo/sangue , Leucemia Eritroblástica Aguda , Masculino , Pessoa de Meia-Idade , Exposição Ocupacional/efeitos adversos , Células Tumorais CultivadasRESUMO
1. NK and T cell functions were measured in peripheral blood lymphocytes of workers occupationally exposed to lead. 2. No differences were found in these functions even in those workers with higher levels of blood and urine lead and urinary delta-ALA than the currently accepted biological limit values as compared to controls. 3. We conclude that high chronic exposure to lead is not associated with an impairment or either T- or NK cell functions in man.