[Effectiveness of a series of pharmacological substances in liver ischemia]. / Issledovanie éffektivnosti riada farmakologicheskikh preparatov pri ishemii pecheni.

Antiischemic activity of alpha-tocopherol, prednisolone, T-407 and T-408 on functions of liver tissue was studied after 90 min contraction of hepatoduodenal ligament in 61 animals. All the preparations studied exhibited the antiischemic protection of liver tissue; the most effective drugs proved to be T-408 and prednisolone.

[The action of amtizol and gutimin on the respiratory metabolism of the neuron]. / Deistvie amtizola i gutimina na dykhatel'nyi metabolizm neirona.

The effects of antihypoxants gutimine and amtisole on oxygen consumption by the intact nerve cell of the invertebrate and the activity of NADN-DH and SDH-dependent ways of oxidation in the cell were studied. Under normoxia gutimine inhibited the nerve cell respiration and decreased the activity of NADN-DN and SDH-dependent ways of oxidation by 15% and 5% respectively. Amtisole activated the neuron respiration increasing the activity of NADN-DH-dependent way of oxidation. Both antihypoxants, despite the fact that they refer to the same class of compounds, have different mechanisms of action on the neuron metabolism. Gutimine appears to be a pharmacological agent, protector, amtisole as an initiator of the active adaptative reorganization of the intracellular metabolism.

[Radiation protection of mice with hypoxic gas mixtures after administration of anti-hypoxic agents]. / Radiozashchita myshei gipoksicheskimi gazovymi smesiami na fone vvedeniia antigipoksantov.

It is shown that such substances as gutimine, antizol and mexamine increases the resistance of animals to short-term breathing of gas mixtures containing 6 and 5% oxygen. Even if some of them decrease the degree of radioprotective effect of hypoxia, they afford the possibility to safe use of breathing mixtures with lower oxygen content than endured by intact animals, with the resulting increase in radioprotection. Thus the antihypoxic substances can be tested during hypoxiradiotherapy of human tumors.

[Mechanism of the antihypoxic action of zinc compounds]. / Mekhanizm protivogipoksicheskogo deistviia soedinenii tsinka.

It was established in experimental normobaric and hypobaric hypoxia and hemic hypoxia induced by carbon monoxide poisoning that zinc compounds administered in a dose of 0.15 mA/kg have a marked prophylactic protective effect. The mechanism of action of zinc compounds consists in changes of oxygen transport blood function. It was shown that interaction of the hemoglobin molecule with zinc ion brings about an increase in Hb affinity for O2 (the left drive of the oxyhemoglobin dissociation curve), a reduction in cooperative interaction of hemoglobin subunits, and a relative decrease in hemoglobin affinity for carbon monoxide. The leading defence mechanism against hypoxic hypoxia is the left drive, the mechanism of defence against carbon monoxide protection consists in the lowering of the "hem-hem" cooperation and of the relative hemoglobin affinity for carbon monoxide.