RESUMO
OBJECTIVE: To assess the effectiveness and survival of ustekinumab (UST) among patients with psoriatic arthritis (PsA) treated under routine clinical care. METHODS: Multicenter study. Epidemiological and clinical data was collected through electronic medical records of all patients with PsA who started UST in 15 hospitals of Spain. RESULTS: Two hundred and one patients were included, 130 (64.7%) with 45 mg and 71 (35.3%) with 90 mg. One hundred and thirty one patients (65.2%) had previously received another biological therapy. The median baseline DAS 28 ESR was 3.99, and Psoriasis Area and Severity Index (PASI) was 3. Overall, there was a significant decrease in DAS66/68 CRP, swollen joint count (SJC), tender joint count (TJC), and PASI in the first month of treatment, with earlier improvement in skin (PASI) than joints outcomes. Survival was numerically lower in patients with UST 45 mg (58.1%) than 90 mg (76.1%), although significant differences were not found (p = 0.147). When comparing naïve and < 1 TNF blocker versus > 2 TNF blocker-experienced patients, a significantly earlier response was seen in the former group regarding SJC (p = 0.029) at 1 month. Fifty-one patients (25.3%) stopped UST due to joint inefficacy and 4 patients due to adverse events (1.9%). Drug survival was significantly better in patients with fewer lines of previous biological agents (p = 0.003 for < 1 TNF blocker versus > 2 TNF blocker users). CONCLUSIONS: UST was effective in PsA patients in a routine clinical care setting. Patients with UST 90 mg and fewer lines of previous biologics achieved better and faster responses. Key Points ⢠Largest cohort of patients with PsA in treatment with UST with specific rheumatological indication. ⢠First cohort of patients with PsA comparing effectiveness of UST according to 45/90 mg dose.
Assuntos
Antirreumáticos , Artrite Psoriásica , Psoríase , Antirreumáticos/uso terapêutico , Artrite Psoriásica/tratamento farmacológico , Humanos , Psoríase/tratamento farmacológico , Índice de Gravidade de Doença , Espanha , Resultado do Tratamento , Ustekinumab/uso terapêuticoRESUMO
FOUNDATION: Bone Paget's disease (BPD) is a focal disorder of bone remodeling of unknown etiology that affects mainly patients older than 50 years. BPD is after osteoporosis the most frequent osteopathy of the western world and was described for the first time in 1876 by Sir James Paget who called it osteitis deformans. PATIENTS AND METHODS: We present two patients with BPD younger than 40 years. In this report their clinical, analytical, diagnostic, and therapeutic manifestations are described, with the findings of bone biopsy in one of them. Is noteworthy to us the younger age of the patients, rare for this disease, which means that we have carried out the follow-up of the cases. CONCLUSION: In a young adult with high phosphatase alkaline values we will include BPD in the differential diagnosis.
Assuntos
Osteíte Deformante/diagnóstico por imagem , Adulto , Remodelação Óssea/fisiologia , Diagnóstico Diferencial , Humanos , Masculino , Osteíte Deformante/diagnóstico , Osteíte Deformante/tratamento farmacológico , Tomografia Computadorizada por Raios XRESUMO
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Assuntos
Criança , Adolescente , Masculino , Humanos , Terminologia , Streptococcus pneumoniae , Bacteriemia , Sepse , Talassemia beta , Neisseria meningitidis , Artrite , Diagnóstico Diferencial , Haemophilus influenzaeRESUMO
No disponible
