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1.
Rev Neurol ; 28(2): 158-64, 1999.
Artigo em Espanhol | MEDLINE | ID: mdl-10101785

RESUMO

INTRODUCTION: Muscular dystrophies due to calpain deficiency are the first example of a muscular dystrophy due to the mutation of a gene codifying for a non-structural enzymatic protein of unknown function and substrate. DEVELOPMENT: More than 70 mutations have been described in the gene structure, localized to chromosome 15. Although the time course and topography is fairly homogeneous, correlation between the different mutations and the phenotype has still to be analyzed. The age of onset of symptoms is usually between 8 and 14, with no difference between the sexes. There is a slow but uniformly progressive course starting in the pelvis and extending to the shoulder and the distal musculature. Almost all patients are confined to a wheelchair twenty years after onset of the disease. There is no facial, oculomotor or bulbar involvement and gemellar pseudohypertrophy is rare. However, a winged scapula and marked lumbar hyperlordosis is universal. No cardiac or cognitive changes have been observed. Muscle CT shows a pattern of atrophy, mainly of the posterior and medial muscle compartments and of the posterosuperficial group of the legs, which varies depending on the time the disorder has been present. This condition is the commonest etiological group of the dystrophy syndromes, especially of those of late infancy or juvenile onset, in the open populations studied to date. Muscle biopsy, stained by all methods available, is essential to rule out other types of progressive dystrophies secondary to deficiencies of structural proteins.


Assuntos
Calpaína/deficiência , Calpaína/genética , Distrofias Musculares/genética , Adulto , Biópsia , Criança , Pré-Escolar , Diagnóstico Diferencial , Glicoproteínas/genética , Humanos , Músculo Esquelético/patologia , Distrofias Musculares/diagnóstico , Mutação Puntual/genética
2.
Rev Laryngol Otol Rhinol (Bord) ; 118(3): 183-8, 1997.
Artigo em Francês | MEDLINE | ID: mdl-9637108

RESUMO

Lingual thyroid and intra lingual thyro-glossal cyst are two benign tumours of similar embryological pathogenesis respectively with the arrest in the ectopic position of the thyroid gland during its downward migration and from abnormal persistence of the thyro-glossal tract for the cyst. The occurrence of lingual thyroid is rare 1/100,000 patients and outnumbers the incidence of intra-lingual cyst which represents an estimated 2.1% of the thyro-glossal cysts or fistulas. Both lesions are a rare cause of dysphagia and dyspnoea due to oropharyngeal obstruction, and radionuclide scintigraphy combined with CT and/or MRI will establish the diagnosis. Surgical pharyngotomy with an infra-hyoid approach provides excellent access to the lesions and complete removal of the tumours.


Assuntos
Coristoma , Cisto Tireoglosso , Glândula Tireoide , Doenças da Língua , Adolescente , Idoso , Coristoma/diagnóstico , Coristoma/cirurgia , Coristoma/terapia , Humanos , Masculino , Cisto Tireoglosso/diagnóstico , Cisto Tireoglosso/cirurgia , Cisto Tireoglosso/terapia , Doenças da Língua/diagnóstico , Doenças da Língua/cirurgia , Doenças da Língua/terapia
3.
Rev Laryngol Otol Rhinol (Bord) ; 110(4): 423-5, 1989.
Artigo em Francês | MEDLINE | ID: mdl-2636742

RESUMO

The Galen's anastomosis connects superior and recurrent laryngeal nerves and its anatomy and physiology still remain unknown. In humans it can be found in 30 to 60% of cases, according to classical anatomy books. In this study the authors report the anatomy of 47 fresh half-larynx. They have demonstrated the invariable existence of an anastomosis between superior and recurrent laryngeal nerves, either as a single nerve, or as a plexus.


Assuntos
Nervos Laríngeos/anatomia & histologia , Nervo Laríngeo Recorrente/anatomia & histologia , Humanos , Nervos Laríngeos/fisiologia , Nervo Laríngeo Recorrente/fisiologia
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