[Research of interrelations of persistention-factors for sexual-transmitted infections].

Two and more of sexual-transmitted infections present in most quantity of cases with persistent form of infection, then with transitory form of infection. Activation of immune system with papilloma-virus infection do initiality for elimination of virus from organism and stopped next development of infection in organism, development of oncologic diseases, persistent of virus in organism.

[Analysis of the etiological structure of sexually transmitted infections and immunological responsiveness in women with papillomavirus infection of the cervix uteri].

Two sexually transmitted infections or more were more frequently encountered in persistent papillomavirus infection (PVI) than those in transient PVI. The found immunological parameters in PVI arrested further infection progression, suppressed the persistence of human papillomavirus infection types 16 and 18, and prevented related cancer. This might eliminate the virus from the body.

[Clinical, epidemiological, and pathogenetic aspects of formation of persisting forms of high oncogenic risk papillomavirus infection in women].

AIM: To reveal factors related with presence of human papillomavirus in women. MATERIALS AND METHODS: Nine hundred and fifty women of childbearing age from 18 to 45 years old (30 of them--almost healthy) were examined. Samples of epithelium of urogenital tract obtained by scrapings were tested for the presence of urogenital infections by real-time polymerase chain reaction. Colposcopy, cytologic study, and ultrasound examination of pelvic organs were conducted. RESULTS: Human papillomaviruses types 16 and 18 were detected in 41% of studied women. Of them, persisting form of papillomavirus infection was identified in 38%. Following factors promoted the development of persisting papillomavirus infection in women: age under 21 years, presence of pelvic inflammatory disease (endometritis, salpingoophoritis), cervical ectopy, use of untrauterine devices, oncologic diseases in family history, and presence of pointed condylomas. Signs specific for chronic inflammatory disease of cervix were observed significantly more frequently in women with persisting papillomavirus infection. CONCLUSION: Association between presence of chronic inflammatory diseases of female reproductive system, related with different adverse factors, and persistence of human papillomavirus of high oncogenic risk in women.