RESUMO
It was found therapeutic-preventive effectiveness of antioxidants (1,4-dihydropyridine derivatives) at poisoning with malathion insecticide. The effect of 1,4-dihydropyridine derivatives can be attributed to a prevention of lipid peroxidation. Antioxidants do not affect the toxicity of 0,0-dimethyl-0-2,2-dichlorvinylphosphate. Thus, antioxidants are pathogenetic drugs for treatment of poisonings with cholinesterase inhibitors.
Assuntos
Antioxidantes/farmacologia , Inibidores da Colinesterase/intoxicação , Animais , Antioxidantes/uso terapêutico , Di-Hidropiridinas/farmacologia , Di-Hidropiridinas/uso terapêutico , Peroxidação de Lipídeos/efeitos dos fármacos , Malation/intoxicação , Masculino , Camundongos , RatosRESUMO
A biological method for determination of geliomycin activity using agar diffusion is described. A nutrient medium containing Hottinger broth up to 35 mg per cent of amine nitrogen, 1.5 percent of agar-agar, tap water, pH 7.8 to 8.0 was used. Bacillus subtilis ATCC 6633 served as the test-culture. Geliomycin was dissolved in 0.1 N sodium hydroxide solution.