[Perspective applications of multi-species probiotics in the prevention of antibiotic-associated diarrhea].

The problem of antibiotic-associated conditions is one of the most actual problems of clinical practice. The antibiotic-associated diarrhea is a multidisciplinary problem. Investigations of the small intestine microecological status and assessment of microflora at the patients receiving antibiotics testifies to dysbiosis existence. In article results of open-label investigation of a multispecies probiotic RioFlora Balance using for antibiotic-associated diarrhea prophylaxis in patients used antibacterial therapy are presented.

[Metocinium iodide application in patients with irritable bowel syndrome].

In this article result of medication methocinium iodide (Methacin) using at patients with irritable bowel syndrome are observed.

[Infection agents and irritable bowel syndrome].

The discussion concerns onset and pathogenesis of functional intestinal diseases. Current data are presented on association of functional intestinal diseases with different infectious agents with illustration on the model of postinfectious irritable colon syndrome (ICS). ICS-like conditions in patients who had previously intestinal infections are considered.

[Use of Saccharomyces boulardii in treating patients inflammatory bowel diseases (clinical trial)].

The aim of the clinical research was to study the efficacy of Saccharomyces boulardii in treatment of patients with Inflammatory Bowel Diseases. Results of investigation demonstrate more rapid regression of intestinal dyspepsia symptoms, decreasing clinical activity of IBD and improvement of intestinal microbiota composition in IBD patients have been treated by Saccharomyces boulardii. Lyophilized Saccharomyces boulardii are compatible with medical agents of the standard IBD therapy and have high level of safety.

[Prospects for using ladasten preparations in patients with irritable bowel syndrome].

Irritable bowel syndrome is one of the most frequent diseases of the digestive system. Psychodiagnostic investigation of patients with IBS testifies to presence of asthenic frustration. In article results of preparation Ladasten use are presented in therapy of patients with irritable bowel syndrome.

[Functional food and psycho-intellectual abilities of man: the point of contact].

According to the 1996 WHO Report, the world is heading for a major crisis in public health as outbreaks of new and re-emerging infectious diseases are striking at increasing frequencies within the past 10 to 15 years. The given information is true not only for an infection. On the other side eventually a food of the persons considerably changes. The urgent question which needs to be addressed is the nutrition modification and optimization for public health improvement.

[Combined treatment of gastric ulcers induced by nonsteroid antiinflammatory drugs. Results of 4-week population-based controlled trial of efficacy of proton pump inhibitor combination with tripotassium bismuth dicitrate].

AIM: To study efficacy of a combination of proton pump inhibitor (PPI) and bismuth tripotassium dicitrate (BTD) in gastric ulcers (GU) induced by non-steroid anti-inflammatory drugs (NSAD) in rheumatic patients with factors affecting PPI efficacy. MATERIAL AND METHODS: Fifty rheumatic patients entered the study (5 males and 45 females, mean age 63.5 +/- 6.2 years) with NSAD-induced GU. Criteria of participation in the study: ulcer size > 1.0 cm, 2 and more ulcers, administration of glucocorticoids (GC) and/or cytotoxic drugs. The patients were divided into two groups. Group 1 patients received omeprasol 20 mg twice a day + BTD 240 mg twice a day; group 2 patients received omeprasol alone 20 mg twice a day. The groups were matched by demographic and clinical parameters, consisted mainly of women with rheumatoid arthritis, most of the patients took GC, methotrexate or leflunamid. The result of the treatment was evaluated by the findings of endoscopic examination 4 and 8 weeks after treatment. RESULTS: Three patients from group 1 and 2 patients from group 2 were withdrawn from the study. For 4 weeks ulcer heeling was achieved in 15 patients of group 1 (68.2%) and 8 patients of group 2 (34.8%), p = 0.038. On week 8 ulcers healed in 86.3 and 78.3% patients, respectively. Severe side effects were absent. CONCLUSION: Combination of omeprasol with BTD stimulated heeling of NSAD-induced gastric ulcer.

[Effect pf cholecystectomy on bile lithogenecity and morphological changes in the pancreas of patients with chronic biliary pancreatitis].

The authors consider mechanism of biliary dysfunction in cholelithiasis responsible for the development of secondary changes in parenchyma and pancreatic ductal system and effect of cholecystectomy on bile lithogenecity in patients with chronic biliary pancreatitis. A high-precision technique for instrumental diagnosis (endosonography) yielded data on the role of microliths and biliary sludge in pathogenesis of chronic biliary pancreatitis. The necessity to use ursodeoxycholic acid derivatives for the treatment of this pathology is substantiated.

[Gastroesophageal reflux disease: pathogenetic basis of differentiated tactics of treatment].

The article contains information about severe side effects of long-term acid suppression with non-select proton pump inhibitors (PPI) treatment of gastroesophageal reflux disease (GERD). As far as concern patients with heartborn without esophagitis (non-erosive GERD) using PPI doesn't correspond the pathogenesis and hardly has any advantages. Therapy with gastric acidity inhibitors increases risk of acute gastroenteritis and community-acquired pneumonia. Quality of life is rising and symptoms of gastro-esophageal reflux are getting away thanks to topical harmless treatment GERD without severe esophagitis Pepsan-R.

[The role of genetic features of Helicobacter pylori in pathogenesis of digestive system diseases: from theory to practice].

In this article the comparative analysis of various methods of Helicobacter pylori verification is shown. Also algorithm of optimization of helicobacteriosis diagnostic, developed on the basis of a comparative estimation of results of various diagnostic techniques is presented. According to this algorithm, for increase of accuracy of helicobacteriosis diagnostic it is recommended to use at least two, and it is better three diagnostic methods: the combination of fast urease test or Helic-test with a histologic method (biopsy material from a stomach corpus) or polymerase chain reaction (ureC gene detection) is preferable. For an efficiency estimation of eradication therapy we recommend "Helic-test" as an effective noninvasive method that is especially important for children.

[Pathomorphosis of anxiety disorder in patients with intestinal dysbiosis].

It is known, that anxiety is one of the most wide-spread mental disorders in-between psychiatric state and it takes part in pathogenesis a lot of somatic diseases as well. At the same time the host bowel microbiota participates in metabolic control of vital human functions such as mood and behavioural reactions. This title connection reveals some new therapeutic opportunity in treatment of psychiatric disorders that based on using with probiotics. In case non-clinically significant anxiety it is claimed to use probiotic (Enterol) however in case clinically significant anxiety it is claimed to use non-benzodiazepine tranquilizer (Stresam).

[Feeding behavior of people in advanced age].

In the article the questions of eating attitudes of people in advanced age are considered. Inspection of 54 people of St. Petersburg in the age from 65 to 84 included questioning (biological, social and questions of eating contents), estimation of eating attitude (the eating attitude test EAT-26, the Dutch eating behaviour questionnaire) and psychological testing (techniques of an estimation of complaints, attitudes, levels of anxiousness, depression, astenia, aggression and quality of life). Symptoms of eating disorders with restrictive and emotional tendencies were registered in 14,8% of people of advanced age. Communications of eating attitude with social factors, eating preferences, application of a diet, a degree of a dissatisfaction of body weight, arterial blood pressure and psychological parameters have been revealed.