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Pathol Int ; 58(6): 402-5, 2008 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-18477221

RESUMO

Described herein is a case of thymic extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. Using immunohistochemical double staining it was found that most of the thymic lymphoid follicles in this case possessed cytokeratin-positive and follicular dendritic cell (FDC) marker-positive cells. Moreover, using immunoelectron microscopy it was confirmed that some of the double-positive cells were thymic epithelial cells. The candidate of cytokeratin subtype expressed on the double-positive cells was cytokeratin 1 (CK1), which was expressed only by the epithelium of Hassall's corpuscles in thymuses from age-matched patients with myasthenia gravis. The present case indicates a possibility that some thymic epithelial cells become FDC, although it was uncertain whether they were derived from the epithelia of Hassall's corpuscles or whether they were at the same differentiation stage as Hassall's corpuscles.


Assuntos
Células Dendríticas Foliculares/metabolismo , Linfoma de Zona Marginal Tipo Células B/metabolismo , Timo/metabolismo , Neoplasias do Timo/metabolismo , Biomarcadores Tumorais/metabolismo , Células Dendríticas Foliculares/patologia , Células Epiteliais/metabolismo , Células Epiteliais/ultraestrutura , Feminino , Humanos , Imuno-Histoquímica , Linfoma de Zona Marginal Tipo Células B/patologia , Linfoma de Zona Marginal Tipo Células B/cirurgia , Microscopia Imunoeletrônica , Receptores de Complemento 3d/análise , Timectomia , Timo/patologia , Neoplasias do Timo/patologia , Neoplasias do Timo/cirurgia
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