RESUMO
Quinolactacide isolated from Penicillium citrinum F 1539 was synthesized and evaluated for its insecticidal activities. The key steps of the total synthesis were an acyl migration reaction of the enol ester intermediate and dehydrogenation of tetrahydroquinolactacide with manganese dioxide. The synthesized quinolactacide showed 100% and 42% mortality against the green peach aphid (Myzus persicae) and diamondback moth (Plutella xylostella) at 500 ppm, respectively.
Assuntos
Inseticidas/síntese química , Inseticidas/farmacologia , Compostos de Manganês/química , Óxidos/química , Quinolonas/síntese química , Quinolonas/farmacologia , Acilação , Animais , Afídeos/efeitos dos fármacos , Hidrogenação , Inseticidas/química , Estrutura Molecular , Mariposas/efeitos dos fármacos , Quinolonas/químicaRESUMO
By a screening program searching for new pesticides from fungal sources, an insecticidal compound was isolated from Penicillium citrinum F 1539. The compound, named quinolactacide, was novel and showed 88% mortality against green peach aphids (Myzus persicae) at 250 ppm. Its structure was determined by spectroscopic techniques.
